Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/124281
Evolutionary conserved role of eukaryotic translation factor eIF5A in the regulation of actin-nucleating formins
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Elongation factor eIF5A is required for the translation of consecutive prolines, and was shown in yeast to translate polyproline-containing Bni1, an actin-nucleating formin required for polarized growth during mating. Here we show that Drosophila eIF5A can functionally replace yeast eIF5A and is required for actin-rich cable assembly during embryonic dorsal closure (DC). Furthermore, Diaphanous, the formin involved in actin dynamics during DC, is regulated by and mediates eIF5A effects. Finally, eIF5A controls cell migration and regulates Diaphanous levels also in mammalian cells. Our results uncover an evolutionary conserved role of eIF5A regulating cytoskeleton-dependent processes through translation of formins in eukaryotes.
Matèries
Matèries (anglès)
Citació
Citació
MUÑOZ SORIANO, Verónica, DOMINGO MUELAS, Ana, LI, Tianlu, GAMERO, Esther, BIZY, Alexandra, FARIÑAS, Isabel, ALEPUZ, Paula, PARICIO, Nuria. Evolutionary conserved role of eukaryotic translation factor eIF5A in the regulation of actin-nucleating formins. _Scientific Reports_. 2017. Vol. 7. [consulta: 21 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/124281]