Miniatura

Fitxers

1-s2.0-S003493562400015X-main.pdf (408.51 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2024-08-01

Llicència de publicació

cc by (c) Nagore, D. et al, 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/215766

Ácido úrico y daño renal agudo en pacientes con alto riesgo de desarrollar daño renal agudo sometidos a cirugía cardiaca: cohorte prospectiva multicéntrica

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1016/j.redar.2023.09.005

Resum

Purpose: It is unclear whether preoperative serum uric acid (SUA) elevation may play a role in the development of acute kidney injury (AKI) associated with cardiac surgery (CSA-AKI). We conducted a cohort study to evaluate the influence of preoperative hyperuricemia on AKI in patients at high risk for developing SC-AKI. Design: Multicenter prospective international cohort study. Setting: Fourteen university hospitals in Spain and the United Kingdom. Participants: We studied 261 consecutive patients at high risk of developing CSA-AKI, according to a Cleveland score >4 points, from July to December 2017. Interventions: None. Measurements and Main Results: AKIN criteria were used for the definition of AKI. Multivariable logistic regression models and propensity score-matched pairwise analysis were used to determine the adjusted association between preoperative hyperuricemia (> = 7 mg/dL) and AKI. Elevated preoperative AUS (> = 7 mg/dL) was present in 190 patients (72.8%), whereas CSA-AKI occurred in 145 patients (55.5%). In multivariable logistic regression models, hyperuricemia was not associated with a significantly increased risk of AKI (adjusted Odds Ratio [OR]: 1.58; 95% confidence interval [CI]: 0.81-3; p = 0.17). In propensity score-matched analysis of 140 patients, the hyperuricemia group experienced similar adjusted odds of AKI (OR 1.05, 95% CI 0.93-1.19, p = 0.37). Conclusions: Hyperuricemia was not associated with an increased risk of AKI in this cohort of patients undergoing cardiac surgery at high risk of developing CSA-AKI. (c) 2024 The Author(s). Published by Elsevier Espania, S.L.U. on behalf of Sociedad Espaniola de Anestesiologia, Reanimacion y Terapeutica del Dolor. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Matèries

Cirurgia cardíaca, Malalties del ronyó

Matèries (anglès)

Heart surgery, Kidney diseases

Citació

Col·leccions

Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

NAGORE, D., CANDELA, A., BÜRGE, M., TAMAYO, E., MURIE-FERNÁNDEZ, M., VIVES, M., MONEDERO, P., ÁLVAREZ, J., MENDEZ, Esther, PASQUALETTO, Alberto, MON, T., PITA, R., VARELA, M. a., ESTEVA, C., PEREIRA, M. a., SANCHEZ, J., RODRIGUEZ, M. a., GARCIA, A., CARMONA, P., LÓPEZ, M., PAJARES, A., VICENTE, R., APARICIO, R., GRAGERA, I., CALDERÓN, E., MARCOS, J.m., GÓMEZ, L., RODRÍGUEZ, J. m., MATILLA, A., MEDINA, A., HERNÁNDEZ, A., MORALES, L., SANTANA, L., GARCIA, E., MONTESINOS, S., MUÑOZ, P., BRAVO, B., BLANCO, V.. Ácido úrico y daño renal agudo en pacientes con alto riesgo de desarrollar daño renal agudo sometidos a cirugía cardiaca: cohorte prospectiva multicéntrica. _Revista Española de Anestesiología y Reanimación_. 2024. Vol. 71, núm. 7, pàgs. 514-521. [consulta: 27 de gener de 2026]. ISSN: 2340-3284. [Disponible a: https://hdl.handle.net/2445/215766]

Exportar metadades

JSON - METS

Compartir registre