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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/119078
Drug-Resistant Polymorphisms and Copy Numbers in Plasmodium falciparum, Mozambique, 2015
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One of the fundamental steps toward malaria control is the use
of antimalarial drugs. The success of antimalarial treatment can
be affected by the presence of drug-resistant populations of
Plasmodium falciparum. To assess resistance, we used molecular
methods to examine 351 P. falciparum isolates collected from 4
sentinel sites in Mozambique for K13, pfmdr1, pfcrt, and pfdhps
polymorphisms and for plasmepsin2 (pfpm2) and pfmdr1 copy
numbers. We found multiple copies of pfpm2 in 1.1% of isolates.
All isolates carried K13 wild-type alleles (3D7-like), except 4
novel polymorphisms (Leu619Leu, Phe656Ile, Val666Val,
Gly690Gly). Prevalence of isolates with pfcrt mutant (K76T)
allele was low (2.3%). Prevalence of isolates with pfdhps mutant
alleles (A437G and K540E) was >80%, indicating persistence of
sulfadoxine/pyrimethamine resistance; however, markers of
artemisinin were absent, and markers of piperaquine resistance
were low. Piperaquine resistance isolates may spread in
Mozambique as dihydroartemisinin/piperaquine drug pressure
increases.
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GUPTA, Himanshu, et al. Drug-Resistant Polymorphisms and Copy Numbers in Plasmodium
falciparum, Mozambique, 2015. Emerging Infectious Diseases. 2018. Vol. 24, num. 1, pags. 40-48. ISSN 1080-6040. [consulted: 18 of June of 2026]. Available at: https://hdl.handle.net/2445/119078