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Llora_Batlle_O_Sci_Adv_2020.pdf (1.04 MB)

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Data de publicació

2020

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cc by (c) Llorà Batlle, Oriol et al, 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/182834

Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum

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Recurs relacionat

http://dx.doi.org/ 10.1126/sciadv.aaz5057

Resum

--- - i: - Plasmodium falciparum content: - "Malaria transmission requires that some asexual parasites convert into sexual forms termed gametocytes. The initial stages of sexual development, including sexually committed schizonts and sexual rings, remain poorly haracterized, mainly because they are morphologically identical to their sexual counterparts and only a small subset of parasites undergo sexual development. Here, we describe a system for controlled sexual conversion in the human malaria parasite " - ", based on conditional expression of the PfAP2-G transcription factor. Using this system, ~90 percent of the parasites converted into sexual forms upon induction, enabling the characterization of committed and early sexual stages without further purification. We characterized sexually committed schizonts and sexual rings at the transcriptomic and phenotypic levels, which revealed down-regulation of genes involved in solute transport upon sexual commitment, among other findings. The new inducible lines will facilitate the study of early sexual stages at additional levels, including multiomic characterization and drug susceptibility assays."

Matèries

Malària, Microbiologia mèdica

Matèries (anglès)

Malaria, Medical microbiology

Citació

Col·leccions

Articles publicats en revistes (ISGlobal)

Citació

LLORÀ BATLLE, Oriol, et al. Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum. Science advances. 2020. Vol.  vol 6, num. num 24. ISSN 2375-2548. [consulted: 4 of August of 2026]. Available at: https://hdl.handle.net/2445/182834

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