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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/175233
SeDeM Diagram: A New Expert System for the Formulation of Drugs in Solid Form
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Abstract
The SeDeM expert system is a methodology which is applied in preformulation and
formulation studies of medicines specifically in solid dosage forms. This system informs on
the physical profile of powdered substances (APIs and excipients) used to formulate drugs
(Suñé et al, 2005; García et al, 2010; Aguilar et al, 2009). By determining whether powders
(API or excipient) are suitable for direct compression, the SeDeM profile will inform about
the advantages and gaps of those powdered substance to be used in direct compression, so
the system informs on whether the direct compression method is appropriate (e.g.. wet
granulation should be applied before compression).
The characterization of powdered substances by SeDeM facilitates the identification of the
characteristics that require amendment in order to obtain tablets by direct compression. This
system thus provides information that will ensure the robust design of the formulation in
the final product.
This new method is based on the selection and application of several parameters that the
formulation must fulfill to ensure a successful tablet elaborated by direct compression...
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SUÑÉ I NEGRE, Josep M. (Josep Maria), et al. SeDeM Diagram: A New Expert System for the Formulation of Drugs in Solid Form. Chapter 2 in: Vizureanu. Petrică. 2011. Expert Systems for Human. Vol. IntechOpen. [consulted: 14 of June of 2026]. Available at: https://hdl.handle.net/2445/175233