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2016-08-30

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cc-by (c) Hernández, Sandra et al., 2016
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/112562

Mitochondrial toxicity and caspase activation in HIV pregnant women.

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https://doi.org/10.1111/jcmm.12935

Abstract

To assess the impact of HIV-infection and highly active anti-retroviral treatment in mitochondria and apoptotic activation of caspases during pregnancy and their association with adverse perinatal outcome. Changes of mitochondrial parameters and apoptotic caspase activation in maternal peripheral blood mononuclear cells were compared at first trimester of pregnancy and delivery in 27 HIV-infected and -treated pregnant women versus 24 uninfected pregnant controls. We correlated immunovirological, therapeutic and perinatal outcome with experimental findings: mitochondrial DNA (mtDNA) content, mitochondrial protein synthesis, mitochondrial function and apoptotic caspase activation. The HIV pregnancies showed increased adverse perinatal outcome (OR: 4.81 [1.14-20.16]; P < 0.05) and decreased mtDNA content (42.66 ± 5.94%, P < 0.01) compared to controls, even higher in naïve participants. This depletion caused a correlated decrease in mitochondrial protein synthesis (12.82 ± 5.73%, P < 0.01) and function (20.50 ± 10.14%, P < 0.001), not observed in controls. Along pregnancy, apoptotic caspase-3 activation increased 63.64 ± 45.45% in controls (P < 0.001) and 100.00 ± 47.37% in HIV-pregnancies (P < 0.001), in correlation with longer exposure to nucleoside analogues. HIV-infected women showed increased obstetric problems and declined genetic and functional mitochondrial parameters during pregnancy, especially those firstly exposed to anti-retrovirals. The apoptotic activation of caspases along pregnancy is emphasized in HIV pregnancies promoted by nucleoside analogues. However, we could not demonstrate direct mitochondrial or apoptotic implication in adverse obstetric outcome probably because of the reduced sample size.

Subject

Infeccions per VIH, Embaràs, Persones seropositives, Mitocondris

Subject (English)

HIV infections, Pregnancy, HIV-positive persons, Mitochondria

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (BCNatal Fetal Medicine Research Center)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citation

HERNÁNDEZ, Sandra, et al. Mitochondrial toxicity and caspase activation in HIV pregnant women. Journal of Cellular and Molecular Medicine. 2016. Vol. 21, num. 1, pags. 26-34. ISSN 1582-1838. [consulted: 14 of August of 2026]. Available at: https://hdl.handle.net/2445/112562

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