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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/177070
Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial
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Background: Given the limitation of pharmacological treatments to treat cognitive symptoms in patients with Major Depressive Disorder (MDD), cognitive remediation programs has been proposed as a possible procognitive intervention but findings are not conclusive. This study investigates the efficacy of an INtegral Cognitive REMediation (INCREM) that includes a combination of a Functional Remediation (FR) strategy plus a Computerized Cognitive Training (CCT) in order to improve not only cognitive performance but also the psychosocial functioning and the quality of life. Methods: A single blind randomized controlled clinical trial in 81 patients with a diagnosis of MDD in clinical remission or in partial remission. Participants will be randomized to one of three conditions: INCREM (FR + CCT), Psychoeducation plus online games and Treatment As Usual (TAU). Intervention will consist in 12 group sessions, of approximately 110 min once a week. The primary outcome measure will be % of change in psychosocial functioning after treatment measured by the Functional Assessment Short Test (FAST); additionally, number of sick leaves and daily activities will also be recorded as pragmatic outcomes. Discussion: To our knowledge, this is the first randomized controlled clinical trial using a combination of two different approaches (FR + CCT) to treat the present cognitive deficits and to promote their improvements into a better psychosocial functioning. Trial registration: Clinical Trials NCT03624621 . Date registered 10th of August 2018 and last updated 24th August 2018.
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VICENT GIL, Muriel, RAVENTÓS, Beatriz, MARÍN MARTÍNEZ, Eduardo d., GONZÁLEZ SIMARRO, Sara, MARTÍNEZ-ARÁN, Anabel, BONNÍN ROIG, Caterina del mar, TRUJOLS, Joan, PÉREZ BLANCO, Josefina, DE DIEGO ADELIÑO, Javier, PUIGDEMONT, Dolors, SERRA BLASCO, María, CARDONER, N. (narcís), PORTELLA MOLL, María jesús. Testing the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial. _BMC Psychiatry_. 2019. Vol. 19, núm. 1, pàgs. 135. [consulta: 25 de febrer de 2026]. ISSN: 1471-244X. [Disponible a: https://hdl.handle.net/2445/177070]