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2020-03-01

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cc by-nc-nd (c) Alustiza et al., 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/171793

Increased Th17-Related Cytokine Serum Levels in Patients With Multiple Polyps of Unexplained Origin

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https://doi.org/10.14309/ctg.0000000000000143

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OBJECTIVES: Most patientswith multiple colonic polyps do not have a known genetic or hereditary origin. Our aim was to analyze the presence of inflammatory cytokines and levels of glucose, insulin, and C-reactive protein (CRP) in patients with multiple colonic polyps. METHODS: Eighty-three patients with 10 or more adenomatous or serrated polyps and 53 control people with normal colonoscopy were included. Smoking habits were registered, and glucose, CRP, and basal insulin in the serum/blood weremeasured. Quantification of IL-2, IL-4, IL-6, IL-10, IL-11, IL-17A, and IL-23 cytokine levels in the serum was performed by a high-sensitivity enzyme-linked immunosorbent assay. RESULTS: Smoking and diabetesweremore prevalent in those with colonic polyps than in the control people (67% vs 16%, P = 0.001; 11% vs 2%, P = 0.048). In addition, the cytokine serum levels were higher, i.e., IL-2 (P = 0.001), IL-4 (P = 0.001), IL-6 (P = 0.001), IL-17A (P = 0.001), IL-23 (P = 0.014), and CRP (P = 0.003). Adjusting for sex, smoking, and diabetes in amultivariate analysis, IL-2, IL-4, IL-6, IL-17A, and IL-23 remained independently elevated in cases with multiple polyps. DISCUSSION: These results indicate that immune responses mediated by Th17 cells may be involved in the pathogenesis of multiple colonic polyps.

Matèries

Pòlips (Patologia), Citoquines

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Polyps (Pathology), Cytokines

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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ALUSTIZA, Miren, HERNÁNDEZ ILLÁN, Eva, JUÁREZ, Miriam, GINER CALABUIG, Mar, MIRA, Cristina, MARTÍNEZ ROCA, Alejandro, BUJANDA, Luis, RODRÍGUEZ MORANTA, Francisco, CUBIELLA, Joaquín, CASTRO, Luisa de, MARÍN GABRIEL, José carlos, HERREROS DE TEJADA, Alberto, FERNÁNDEZ BAÑARES, Fernando, NICOLÁS PÉREZ, David, GIMÉNEZ, Paula, MARTÍNEZ CARDONA, Claudia, FRANCÉS, Rubé, MURCIA, Oscar, JOVER, Rodrigo. Increased Th17-Related Cytokine Serum Levels in Patients With Multiple Polyps of Unexplained Origin. _Clinical and Translational Gastroenterology_. 2020. Vol. 11. [consulta: 25 de febrer de 2026]. [Disponible a: https://hdl.handle.net/2445/171793]

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