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Cost_effectiveness_of_direct_oral_anticoagulants.79.pdf (281.63 KB)

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Article

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2020-09-04

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cc by (c) Hernández Rojas, Zojaina et al., 2020
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/174574

Cost-effectiveness of direct oral anticoagulants versus vitamin K antagonist in atrial fibrillation: A study protocol using Real-World Data from Catalonia (FantasTIC Study)

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https://doi.org/10.1097/MD.0000000000022054

Abstract

Background: Anticoagulant therapy is used for stroke prevention and proved to be effective and safe in the long term. The study aims to analyse the cost-effectiveness relationship of using of direct-acting oral anticoagulants vs vitamin K antagonists to prevent ischaemic stroke in patients with nonvalvular atrial fibrillation, including all the active ingredients marketed in Spain, prescribed for 2 years in the Primary Care service of the Institut Català de la Salut. Methods: Population-based cohort study, in which the cost of the 2 treatment groups will be evaluated. Direct costs (pharmacy, primary care, emergency and hospitalization) and indirect costs (lost productivity) will be included from a social perspective. Effectiveness (assessed as the occurrence of a health event, the 1 of primary interest being stroke) will be determined, with a 2-year time horizon and a 3% discount rate. The average cost of the 2 groups of drugs will be compared using a regression model to determine the factors with the greatest influence on determining costs. We will carry out a univariate ('one-way') deterministic sensitivity analysis. Discussion: We hope to provide relevant information about direct and indirect costs of oral anticoagulants, which, together with aspects of effectiveness and safety, could help shape the consensual decision-making of evaluating bodies.

Subject

Cost de l'assistència sanitària, Catalunya, Assaigs clínics, Anticoagulants (Medicina), Vitamines K

Subject (English)

Cost of medical care, Catalonia, Clinical trials, Anticoagulants (Medicine), Vitamin K

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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HERNÁNDEZ ROJAS, Zojaina, et al. Cost-effectiveness of direct oral anticoagulants versus vitamin K antagonist in atrial fibrillation: A study protocol using Real-World Data from Catalonia (FantasTIC Study). Medicine. 2020. Vol. 99 (36), num. e22054. [consulted: 12 of August of 2026]. Available at: https://hdl.handle.net/2445/174574

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