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2022-08-13

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cc-by (c) Álvarez Zaballos, Sara et al., 2022
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/202163

Multivalvular Endocarditis: A Rare Condition with Poor Prognosis.

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https://doi.org/10.3390/jcm11164736

Abstract

Background. Infective endocarditis (IE) is a severe condition. Our aim was to describe the profile and prognosis of patients with multivalvular infective endocarditis (MIE) and compare them to single-valve IE (SIE). Methods. We used a retrospective analysis of the Spanish IE Registry (2008−2020). Results. From 4064 definite cases of valvular IE, 577 (14.2%) had MIE. In patients with MIE, the most common locations were mitral (552, 95.7%) and aortic (550, 95.3%), with mitral-aortic involvement present in 507 patients (87.9%). The most common etiologies were S. viridans (192, 33.3%) and S. aureus (113, 19.6%). MIE involved only native valves in 450 patients (78.0%). Compared with patients with SIE, patients with MIE had a similar age (69 vs. 67 years, respectively, p = 0.27) and similar baseline characteristics, but were more frequently men (67.1% vs. 72.9%, p = 0.005) and had a higher incidence of intracardiac complications (36.2% vs. 50.4%, p < 0.001), heart failure (42.7% vs. 52.9%, p < 0.001), surgical indication (67.7 vs. 85.1%, p < 0.001), surgery (46.3% vs. 56.3%), and in-hospital mortality (26.9% vs. 34.3%, p < 0.001). MIE was an independent predictor of in-hospital mortality (odds ratio (OR) 1.3, 95% confidence interval (CI) 1.1−1.7, p = 0.004) but did not have an independent association with 1-year mortality (OR 1.1, 95% CI 0.9−1.4, p = 0.43). Conclusions. About one-seventh of the valvular IE patients had MIE, mainly due to mitral-aortic involvement. MIE is associated with a poor in-hospital prognosis. An early diagnosis and treatment of IE might avoid its spread to a second valve.

Subject

Endocarditis, Pronòstic mèdic, Vàlvules cardíaques, Mortalitat

Subject (English)

Endocarditis, Prognosis, Heart valves, Mortality

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citation

ÁLVAREZ ZABALLOS, Sara, et al. Multivalvular Endocarditis: A Rare Condition with Poor Prognosis. Journal of Clinical Medicine. 2022. Vol. 11, num. 16, pags. 4736. ISSN 2077-0383. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/202163

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