Miniatura

Fitxers

jcm-12-01329-v2.pdf (921.91 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2023-02-07

Llicència de publicació

cc by (c) Santos García, Diego et al, 2023
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/197671

Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson’s Disease

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.3390/jcm12041329

Resum

Background and objective: Sex plays a role in Parkinson's disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross-sectional and a two-year follow-up analysis were conducted. Univariate analyses and general linear model repeated measure were used. Results: At baseline, data from 681 PD patients (mean age 62.54 +/- 8.93) fit the criteria for analysis. Of them, 410 (60.2%) were males and 271 (39.8%) females. There were no differences between the groups in mean age (62.36 +/- 8.73 vs. 62.8 +/- 9.24; p = 0.297) or in the time from symptoms onset (5.66 +/- 4.65 vs. 5.21 +/- 4.11; p = 0.259). Symptoms such as depression (p < 0.0001), fatigue (p < 0.0001), and pain (p < 0.00001) were more frequent and/or severe in females, whereas other symptoms such as hypomimia (p < 0.0001), speech problems (p < 0.0001), rigidity (p < 0.0001), and hypersexuality (p < 0.0001) were more noted in males. Women received a lower levodopa equivalent daily dose (p = 0.002). Perception of quality of life was generally worse in females (PDQ-39, p = 0.002; EUROHIS-QOL8, p = 0.009). After the two-year follow-up, the NMS burden (Non-Motor Symptoms Scale total score) increased more significantly in males (p = 0.012) but the functional capacity (Schwab and England Activities of Daily Living Scale) was more impaired in females (p = 0.001). Conclusion: The present study demonstrates that there are important sex differences in PD. Long-term prospective comparative studies are needed.

Matèries

Malaltia de Parkinson, Factors sexuals en les malalties

Matèries (anglès)

Parkinson's disease, Sex factors in disease

Citació

Col·leccions

Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

SANTOS GARCÍA, Diego, LAGUNA, Ariadna, HERNÁNDEZ VARA, Jorge, DEUS FONTICOBA, Teresa de, CORES BARTOLOMÉ, Carlos, FEAL PAINCEIRAS, Maria j., ÍÑIGUEZ ALVARADO, Maria cristina, GARCÍA DÍAZ, Iago, JESÚS, Silvia, BOUNGIORNO, Maria teresa, PLANELLAS, Lluís, COSGAYA, Marina, GARCÍA CALDENTEY, Juan, CABALLOL, Núria, LEGARDA, Ines, CABO, Iria, LÓPEZ MANZANARES, Lydia, GONZÁLEZ ARAMBURU, Isabel, ÁVILA RIVERA, Maria a., GÓMEZ MAYORDOMO, Víctor, NOGUEIRA, Víctor, PUENTE, Víctor, DOTOR GARCÍA-SOTO, Julio, BORRUÉ, Carmen, SOLANO VILA, Berta, ÁLVAREZ SAUCO, María, VELA, Lydia, ESCALANTE, Sonia, CUBO, Esther, CARRILLO PADILLA, Francisco, CASTRILLO, Juan c. martínez, SÁNCHEZ ALONSO, Pilar, ALONSO LOSADA, Maria g., LÓPEZ ARIZTEGUI, Nuria, GASTÓN, Itziar, KULISEVSKY, Jaime, MENÉNDEZ GONZÁLEZ, Manuel, SEIJO, Manuel, RÚIZ MARTÍNEZ, Javier, VALERO, Caridad, KURTIS, Mónica, GONZÁLEZ ARDURA, Jessica, ALONSO REDONDO, Ruben, ORDÁS, Carlos, LÓPEZ DÍAZ, Luis m., MCAFEE, Darrian, MARTINEZ MARTIN, Pablo, MIR, Pablo, COPPADIS Study Group. Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson’s Disease. _Journal of Clinical Medicine_. 2023. Vol. 12, núm. 4. [consulta: 24 de gener de 2026]. ISSN: 2077-0383. [Disponible a: https://hdl.handle.net/2445/197671]

Exportar metadades

JSON - METS

Compartir registre