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2025-03-31

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cc by-nc-nd (c) Bento, Leyre et al, 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/222831

Autologous stem cell transplantation for relapsed/refractory large B-cell lymphoma: a multicenter GETH-TC/GELTAMO study

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https://doi.org/10.1182/bloodadvances.2024015415

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We performed a retrospective multicenter study including 791 patients with relapsed/ refractory (R/R) large B-cell lymphoma (LBCL) who underwent autologous stem cell transplantation (ASCT). After a median follow-up of 74 months from infusion, 65% were alive and 84% free of disease. Progression-free survival (PFS) and overall survival (OS) at 6 years were 51% and 63%, respectively. Non-relapse mortality at 1 year was 9%. Age >60 years at ASCT (hazard ratio [HR], 1.31; 95% CI, 1.06-1.62; P = .011), ASCT as >= 3rd line (HR, 1.81; 95% CI, 1.42-2.31; P < .001), and partial response (PR) vs complete response (CR) at ASCT (HR, 1.46; 95% CI. 1.18-1.81; P < .001) were independent variables influencing PFS. Age >60 years at ASCT (HR, 1.62; 95% CI, 1.24-2.12; P < .001), time period before 1 November 2012 (HR, 1.40; 95% CI, 1.07-1.83; P = .014), ASCT as >= 3rd line (HR, 1.77; 95% CI, 1.32-2.37; P < .001), PR vs CR (HR, 1.58; 95% CI, 1.22-2.05; P < .001), and stable disease vs CR pre-ASCT (HR, 3.41; 95% CI, 1.81-6.45; P < .001) were variables associated with worse OS. Refractory/early relapse did not significantly influence survival (6-year PFS and OS in patients with refractory, early, and late relapse were 54% and 64%, 46% and 62%, and 49% and 63%, respectively). To our knowledge, this is the largest series analyzing the efficacy of ASCT in patients with R/R LBCL after rituximab-containing frontline therapy. Our results indicate that ASCT is a curative option for patients with chemosensitive disease.

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Immunosupressió, Limfomes

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Immunosuppression, Lymphomas

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

BENTO, Leyre, GUTIÉRREZ GARCÍA, Antonio manuel, MARTÍNEZ, Carmen, ORTÍ VERDET, María consejo, SORRIBES, Marina, CAROLINA CABALLERO, Ana, PEÑA, Marta, PÉREZ, Ariadna, JIMÉNEZ UBIETO, Ana, MEDINA, Lucía, BASTOS OREIRO, Mariana, FERNÁNDEZ CALDAS-GONZÁLEZ, Paula, NAVARRO, Belén, SALCEDO, Isabel, ABRISQUETA, Pau, ESPAÑOL, Ignacio, CORNAGO NAVASCUES, Javier, MARTÍN MORO, Fernando, GARCÍA, Lucía, GÓMEZ, Pilar, VARELA, María rosario, PUENTE, María, ZANABILI, Joud, ZUDAIRE, Teresa, ZEBERIO, Izaskun, CAMPO, Raquel del, GONZÁLEZ, Leslie, GONZÁLEZ, Pedro, BLÁZQUEZ, Cristina, ROVIRA, Jordina, SITGES, Marta, FRANCH SARTO, Mireia, CABERO, Almudena, MUSSETTI, Alberto, MONTORO, Juan, SAMPOL, Antonia, SUREDA, Anna, CABALLERO, Dolores, MARTÍN GARCÍA-SANCHO, Alejandro. Autologous stem cell transplantation for relapsed/refractory large B-cell lymphoma: a multicenter GETH-TC/GELTAMO study. _Blood Advances_. 2025. Vol. 9, núm. 13, pàgs. 3281-3292. [consulta: 24 de gener de 2026]. ISSN: 2473-9537. [Disponible a: https://hdl.handle.net/2445/222831]

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