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2022-06-01

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/194022

Body weight of newborn and suckling piglets affects their intestinal gene expression

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Modern hyperprolifc sows must deal with large litters (16-20 piglets) which reduce piglet birthweight with a concomitant increase in the proportion of small and intrauterine growth retarded piglets. However, larger litters do not only have a greater variation of piglet weights, but also a greater variation in colostrum and milk consumption within the litter. To further understand the impact that body weight has on piglets, the present study aimed to evaluate the degree of physiological weakness of the smallest piglets at birth and during the suckling period (20 d) compared to their middle-weight littermates through their jejunal gene expression. At birth, light piglets showed a downregulation of genes related to immune response (FAXDC2, HSPB1, PPARGC1α), antioxidant enzymes (SOD2m), digestive enzymes (ANPEP, IDO1, SI), and nutrient transporter (SLC39A4) (P < 0.05) but also a tendency for a higher mRNA expression of GBP1 (infammatory regulator) and HSD11β1 (stress hormone) genes compared to their heavier littermates (P < 0.10). Excluding HSD11β1 gene, all these intestinal gene expression differences initially observed at birth between light and middle-weight piglets were stabilized at the end of the suckling period, when others appeared. Genes involved in barrier function (CLDN1), pro-infammatory response (CXCL2, IL6, IDO1), and stress hormone signaling (HSD11β1) over-expressed compared to their middle-weight littermates (P < 0.05). In conclusion, at birth and at the end of suckling period, light body weight piglets seem to have a compromised gene expression and therefore impaired nutrient absorption, immune and stress responses compared to their heavier littermates.

Matèries

Expressió gènica, Malalties intestinals

Matèries (anglès)

Gene expression, Intestinal diseases

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Articles publicats en revistes (Bioquímica i Fisiologia)

Citació

VILLAGÓMEZ-ESTRADA, Sandra, et al. Body weight of newborn and suckling piglets affects their intestinal gene expression. Journal of Animal Science. 2022. Vol. 100, num. 6, pags. skac161. ISSN 0021-8812. [consulted: 5 of August of 2026]. Available at: https://hdl.handle.net/2445/194022

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