Body weight of newborn and suckling piglets affects their intestinal gene expression

dc.contributor.authorVillagómez-Estrada, Sandra
dc.contributor.authorPérez, José F.
dc.contributor.authorMelo-Durán, Diego
dc.contributor.authorGonzález Solé, Francesc
dc.contributor.authorD'Angelo, Matilde
dc.contributor.authorPérez-Cano, Francisco J.
dc.contributor.authorSolà Oriol, David
dc.date.accessioned2023-02-23T11:46:08Z
dc.date.available2023-02-23T11:46:08Z
dc.date.issued2022-06-01
dc.date.updated2023-02-23T11:46:08Z
dc.description.abstractModern hyperprolifc sows must deal with large litters (16-20 piglets) which reduce piglet birthweight with a concomitant increase in the proportion of small and intrauterine growth retarded piglets. However, larger litters do not only have a greater variation of piglet weights, but also a greater variation in colostrum and milk consumption within the litter. To further understand the impact that body weight has on piglets, the present study aimed to evaluate the degree of physiological weakness of the smallest piglets at birth and during the suckling period (20 d) compared to their middle-weight littermates through their jejunal gene expression. At birth, light piglets showed a downregulation of genes related to immune response (FAXDC2, HSPB1, PPARGC1α), antioxidant enzymes (SOD2m), digestive enzymes (ANPEP, IDO1, SI), and nutrient transporter (SLC39A4) (P < 0.05) but also a tendency for a higher mRNA expression of GBP1 (infammatory regulator) and HSD11β1 (stress hormone) genes compared to their heavier littermates (P < 0.10). Excluding HSD11β1 gene, all these intestinal gene expression differences initially observed at birth between light and middle-weight piglets were stabilized at the end of the suckling period, when others appeared. Genes involved in barrier function (CLDN1), pro-infammatory response (CXCL2, IL6, IDO1), and stress hormone signaling (HSD11β1) over-expressed compared to their middle-weight littermates (P < 0.05). In conclusion, at birth and at the end of suckling period, light body weight piglets seem to have a compromised gene expression and therefore impaired nutrient absorption, immune and stress responses compared to their heavier littermates.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec730300
dc.identifier.issn0021-8812
dc.identifier.urihttps://hdl.handle.net/2445/194022
dc.language.isoeng
dc.publisherAmerican Society of Animal Science
dc.relation.isformatofReproducció del document publicat a: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175296/
dc.relation.ispartofJournal of Animal Science, 2022, vol. 100, num. 6, p. skac161
dc.rights(c) American Society of Animal Science, 2022
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Bioquímica i Fisiologia)
dc.subject.classificationExpressió gènica
dc.subject.classificationMalalties intestinals
dc.subject.otherGene expression
dc.subject.otherIntestinal diseases
dc.titleBody weight of newborn and suckling piglets affects their intestinal gene expression
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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