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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/65265
Noradrenergic stimulation enhances human action monitoring
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Noradrenergic neurotransmission has been associated with the modulation of higher cognitive functions mediated by the prefrontal cortex. In the present study, the impact of noradrenergic stimulation on the human action-monitoring system, as indexed by eventrelated brain potentials, was examined. After the administration of a placebo or the selective 2 -adrenoceptor antagonist yohimbine, which stimulates firing in the locus ceruleus and noradrenaline release, electroencephalograpic recordings were obtained from healthy volunteers performing a letter flanker task. Yohimbine led to an increase in the amplitude of the error-related negativity in conjunction with a significant reduction of action errors. Reaction times were unchanged, and the drug did not modify the N2 in congruent versus incongruent trials, a measure of preresponse conflict, or posterror adjustments as measured by posterror slowing of reaction time. The present findings suggest that the locus ceruleus
noradrenaline system exerts a rather specific effect on human action monitoring.
noradrenaline system exerts a rather specific effect on human action monitoring.
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RIBA, Jordi, RODRÍGUEZ FORNELLS, Antoni, MORTE, Adelaida, MÜNTE, Thomas f., BARBANOJ, Manel j.. Noradrenergic stimulation enhances human action monitoring. _Journal of Neuroscience_. 2005. Vol. 25, núm. 17, pàgs. 4370-4374. [consulta: 21 de gener de 2026]. ISSN: 0270-6474. [Disponible a: https://hdl.handle.net/2445/65265]