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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/220936
Association between routine blood biomarkers and clinical phenotypes and exacerbations in chronic obstructive pulmonary disease
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Introduction: Chronic obstructive pulmonary disease (COPD) is associated with increased lung and systemic inflammation. We aimed to identify associations between easy-to-obtain blood biomarkers and the frequency and severity of exacerbations. Methods: Cross-sectional, multicentre study performed in four centres in Spain, Italy, Bulgaria, and Slovenia. Blood samples were obtained for blood cell count, C-reactive protein (CRP), alpha-1 antitrypsin (AAT) and fibrinogen analysis. The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and eosinophil/basophil ratio (EBR) were calculated. Firstly, patients were divided into clinical phenotypes according to the Spanish guidelines of COPD, and secondly, patients were classified into 2 groups: non-exacerbators (≤1 ambulatory exacerbation in the previous year) and exacerbators (≥2 ambulatory exacerbations or 1 hospitalisation in the previous year). A multivariate stepwise logistic regression model was performed to identify laboratory parameters associated with exacerbators. Results: A total of 355 patients with a mean age 66 years (SD=8.9) were included, and 64% were male. The mean FEV1% (forced expiratory volume in the first second) was 55% (SD=20%), and the mean COPD Assessment Test (CAT) score was 15.6 (SD=7.9). One hundred ninety-six (55.2%) patients were classified in the non-exacerbator group, and 159 (44.8%) were exacerbators. Patients in the exacerbators group presented lower haemoglobin levels (p=0.019) and ERB (p= 0.023) but higher CRP levels (p=0.001). In the multivariate analysis, females, higher levels of CRP, lower FEV1% and low EBR were independently related to exacerbators.
Conclusion: Female sex, having a more severe impairment of lung function, higher CRP levels and a lower EBR are associated with an exacerbator phenotype in COPD.
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NUÑEZ, Alexa, MARRAS, Viviana, HARLANDER, Matevz, MEKOV, Evgeni, ESQUINAS LÓPEZ, Cristina, TUREL, Matjaz, LESTAN, David, PETKOV, Rosen, YANEV, Nikolay, PIRINA, Pietro, NEGRI, Silvia, MIRAVITLLES FERNÁNDEZ, Marc, BARRECHEGUREN, Miriam. Association between routine blood biomarkers and clinical phenotypes and exacerbations in chronic obstructive pulmonary disease. _International Journal of Chronic Obstructive Pulmonary Disease_. 2020. Vol. 15, núm. 681-690. [consulta: 20 de gener de 2026]. ISSN: 1176-9106. [Disponible a: https://hdl.handle.net/2445/220936]