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Autoantibodies against type I IFNs in patients with critical influenza pneumonia
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In an international cohort of 279 patients with hypoxemic influenza pneumonia, we identified 13 patients (4.6%) with autoantibodies neutralizing IFN-alpha and/or -omega, which were previously reported to underlie 15% cases of life-threatening COVID-19 pneumonia and one third of severe adverse reactions to live-attenuated yellow fever vaccine. Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies neutralizing IFN-alpha 2 alone (five patients) or with IFN-omega (eight patients) from a cohort of 279 patients (4.7%) aged 6-73 yr with critical influenza pneumonia. Nine and four patients had antibodies neutralizing high and low concentrations, respectively, of IFN-alpha 2, and six and two patients had antibodies neutralizing high and low concentrations, respectively, of IFN-omega. The patients' autoantibodies increased influenza A virus replication in both A549 cells and reconstituted human airway epithelia. The prevalence of these antibodies was significantly higher than that in the general population for patients <70 yr of age (5.7 vs. 1.1%, P = 2.2 x 10(-5)), but not >70 yr of age (3.1 vs. 4.4%, P = 0.68). The risk of critical influenza was highest in patients with antibodies neutralizing high concentrations of both IFN-alpha 2 and IFN-omega (OR = 11.7, P = 1.3 x 10(-5)), especially those <70 yr old (OR = 139.9, P = 3.1 x 10(-10)). We also identified 10 patients in additional influenza patient cohorts. Autoantibodies neutralizing type I IFNs account for similar to 5% of cases of life-threatening influenza pneumonia in patients <70 yr old.
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ZHANG, Qian, PIZZORNO, Andrés, MIORIN, Lisa, BASTARD, Paul, GERVAIS, Adrian, LE VOYER, Tom, BIZIEN, Lucy, MANRY, Jeremy, ROSAIN, Jérémie, PHILIPPOT, Quentin, GOAVEC, Kelian, CONDINO-NETO, Antonio, DOMINGUEZ PINILLA, Nerea, MEYTS, Isabelle, AYDILLO, Teresa, OKAMOTO, Keisuke, ANDERSON, Mark s., SOUMARÉ, Aïcha, WROBLEWSKI, Isabelle, KARAMITROS, Timokratis, RUIZ HERNANDEZ, José juan, Covid Human Genetic Effort, MEDINA, Rafael a., KISAND, Kai, RAMÍREZ DUQUE, Nieves, FEYS, Simon, ROMERO ORAA, Laura, KUO, Chen-yen, LEI, Wei-te, RESNICK, Igor, QUINTANA MURCI, Lluis, MILNER, Joshua d., ROMBAUTS, Alexander, JEANNE, Michel, GARCÍA SALUM, Tamara, KU, Cheng-lung, VAN DE BEEK, Diederik, HSIEH, Elena w.y., TAL, Galit, FOURNET, Thomas, Cerba Healthcare Group, PATURAL, Hugues, PESOLE, Graziano, ZATZ, Mayana, NOVELLI, Giuseppe, MORIO, Tomohiro, Lyon Antigrippe Working Group, ARIAS, Andrés a., SHAHROOEI, Mohammed, ROVINA, Nikoletta, RODRÍGUEZ-GALLEGO, Carlos, PUEL, Anne, JOUANGUY, Emmanuelle, VINH, Donald c., UDDIN, K.m. furkan, ABEL, Laurent, SU, Helen c., BONNEAUDEAU, Brigitte, HENNY, Joseph, MOGENSEN, Trine h., COBAT, Aurélie, CASARI, Giorgio, SLABY, Ondrej, RAMASWAMY, Sathishkumar, ABELENDA ALONSO, Gabriela, KISAND, Kai, MOREL, Pascal, FRAGKOU, Paraskevi c., ARGAUD, Laurent, CANNET, Dorothée, VANDERBEKE, Lore, BELOT, Alexandre, SHCHERBINA, Anna, AL-MUHSEN, Saleh, BIGGS, Catherine m., BOGUNOVIC, Dusan, GALLIAN, Pierre, HUSEBYE, Eystein, PLANAS, Anna m., HEATH, James r., VON BERNUTH, Horst, KU, Cheng-lung, DUFOUIL, Carole, HAGIN, David, BOLZE, Alexandre, Etablissement Français Du Sang Study Group, FROIDURE, Antoine, FIEVET, Nathalie, LAURENT, Emilie, GALANI, Ioanna evdokia, POTHIER, Pierre, GREGERSEN, Peter k., LEMONNIER, Sylvie, PADEY, Blandine, CARRATALÀ, Jordi, SPAAN, András n., DARMON, Michael, GRIMBACHER, Bodo, PALOMO, Virginia, DEL MAR MUÑOZ GARCIA, Maria, ZAWADZKI, Pawel, HENRICKSON, Sarah e., HAERYNCK, Filomeen, O'FARRELLY, Cliona, MORAND, Patrice, NIUBÓ, Jordi, ROSA CALATRAVA, Manuel, TROUILLET ASSANT, Sophie, LACHAIZE, Morgane, JARVIS, Erich d., OKADA, Satoshi, VANKER, Martti, BRYCESON, Yenan, LING, Yun, COOPER, Megan a., LUCAS, Carrie l., MANIATIS, Tom, GALLARDO RÍOS, Rafaela, ROMERO VÁZQUEZ, Gloria maría, NAVARRETE, Nicolás, RICHARD, Pascale, DESAI, Murkesh, MANSOURI, Davood, CASTAGNOLI, Riccardo, ZINS, Marie, MARÓDI, László, MIRONSKA, Kristina, RAPTI, Vasiliki, BARIS FELDMAN, Hagit, LAU, Yu-lung, POZZETTO, Bruno, BOEUF, Benoit, RENIA, Laurent, TANCEVSKI, Ivan, FERRES, Marcela, FRANCO, José luis, IMAI, Kohsuke, OZCELIK, Tayfun, PAN-HAMMARSTRÖM, Qiang, AL-MULLA, Fahd, PAPE, Jean w., TRIANTAFYLLIA, Vasiliki, RODRÍGUEZ DE CASTRO, Felipe, ETZIONI, Amos, SOUWEINE, Bertrand, PÉREZ DE DIEGO, Rebeca, WAUTERS, Joost, SÁNCHEZ CÉSPEDES, Javier, SÁNCHEZ CORDERO, Maria jose, UDDIN, Mohammed j., SOLÉ VIOLÁN, Jordi, PERROQUIN, Magali, NG, Lisa f.p., FERRERES, José, BRIONES, Marisa, ABOU TAYOUN, Ahmad, LE CORRE, Nicole, SNOW, Andrew l., TEMEL, Şehime gülsün, TSIODRAS, Sotirios, TZOURIO, Christophe, MERINO DÍAZ, Laura, COEURET PELLICER, Mireille, NOTARANGELO, Luigi d., FLAIG, Amandine, JAVOUHEY, Etienne, SAKER, Kahina, TURVEY, Stuart e., PUJOL, Aurora, COGNASSE, Fabrice, SANCHO SHIMIZU, Vanessa, TIBERGHIEN, Pierre, Reipi Inf Working Group, NADIF, Rachel, HANNA, Suhair, RODRÍGUEZ GALLEGO, Carlos, FLORES, Carlos, SEPPÄNEN, Mikko r.j., Constances Cohort, GOLDBERG, Marcel, BRODIN, Petter, ANDREAKOS, Evangelos, LE GOT, Stéphane, OZGULER, Anna, QUENOT, Jean pierre, GARCÍA SASTRE, Adolfo, CHRISTODOULOU, John, NOVELLI, Antonio, PERLIN, David s., CORDERO, Elisa, COLOMB, Benoit, SÄREKANNU, Karita, CUPIC, Anastasija, MEHLAL SEDKAOUI, Souad, SALLETTE, Jérôme, HERNU, Romain, BUSTAMANTE, Carlos d., BONDARENKO, Anastasiia, LINA, Bruno, CONSTANTINESCU, Stefan n., DROLET, Beth a., HALWANI, Rabih, CASALEGNO, Jean sebastien, SCHWEBEL, Carole, SALAMANCA RIVERA, Celia, AIUTI, Alessandro, 3C-Dijon Study, TANGYE, Stuart g., MARTIN, Fernando, DALGARD, Clifton l., RETAMAR GENTIL, Pilar, DEBETTE, Stéphanie, ESPINOSA PADILLA, Sara, HAMZEH COGNASSE, Hind, BELOT, Alexandre, ABEL, Laurent, SOLER PALACÍN, Pere, ABAD ARRANZ, Maria, AGUILAR GUISADO, Manuela, FELLAY, Jacques, MEYTS, Isabelle, CASANOVA, Jean-laurent, GONZÁLEZ GRANADO, Luis ignacio, BUTTE, Manish j., WAUTERS, Joost, ITAN, Yuval, HAERYNCK, Filomeen, ESCORESCA ORTEGA, Ana, PEIGUE LAFEUILLE, Helene, VALIENTE, Adoración, KOLTSIDA, Ourania, EL BAGHDADI, Jamila, TIBERGHIEN, Pierre, BALSERA-MANZANERO, María, ZINS, Marie, HAMMARSTRÖM, Lennart, QUEROMES, Gregory, BOUSFIHA, Ahmed a., ANDREAKOS, Evangelos, NOTARANGELO, Luigi d., DEBETTE, Stéphanie, SEDIVA, Anna, PRANDO, Carolina. Autoantibodies against type I IFNs in patients with critical influenza pneumonia. _Journal of Experimental Medicine_. 2022. Vol. 219, núm. 11. [consulta: 25 de gener de 2026]. ISSN: 1540-9538. [Disponible a: https://hdl.handle.net/2445/191806]