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2017-09-19

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cc by-nc-nd (c) Koepfli et al., 2017
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/119009

Sustained malaria control over an eight-year period in Papua New Guinea: the challenge of low-density asymptomatic infections

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http://dx.doi.org/10.1093/infdis/jix507

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Background: The scale-up of effective malaria control in the last decade has resulted in a substantial decline in the incidence of clinical malaria in many countries. The effects on the proportions of asymptomatic and submicroscopic infections, and on transmission potential are yet poorly understood. Methods: In Papua New Guinea, vector control has been intensified since 2008, and improved diagnosis and treatment introduced in 2012. Cross-sectional surveys were conducted in Madang Province in 2006 (n=1280), 2010 (n=2117) and 2014 (n=2516). Infections were quantified by highly sensitive qPCR and gametocytes by RT-qPCR. Results: P. falciparum prevalence by qPCR decreased from 42% in 2006 to 9% in 2014. P. vivax prevalence decreased from 42% in 2006 to 13% in 2010, but then increased to 20% in 2014. Parasite densities decreased 5-fold from 2006 to 2010; 72% of P. falciparum and 87% of P. vivax infections were submicroscopic in 2014. Gametocyte density and positivity correlated closely with parasitemia, and population gametocyte prevalence decreased 3-fold for P. falciparum and 29% for P. vivax from 2010 to 2014. Conclusions: Sustained control has resulted in reduced transmission potential but an increasing proportion of gametocyte carriers are asymptomatic and submicroscopic and represent a challenge to malaria control.

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Malària, Papua Nova Guinea

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Malaria, Papua New Guinea

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Articles publicats en revistes (ISGlobal)

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KOEPFLI, Cristian, OME-KAIUS, Maria, JALLY, Shadrach, MALAU, Elisheba, MARIPAL, Samuel, GINNY, Jason, TIMINAO, Lincoln, KATTENBERG, Johanna helena, OBADIA, Thomas, WHITE, Michael t., RARAU, Patricia, SENN, Nicolas, BARRY, Alyssa e., KAZURA, James w., MUELLER, Ivo, ROBINSON, Leanne j.. Sustained malaria control over an eight-year period in Papua New
                Guinea: the challenge of low-density asymptomatic infections. _The Journal of Infectious Diseases_. 2017. Vol. 216, núm. 11, pàgs. 1434–1443. [consulta: 22 de gener de 2026]. ISSN: 0022-1899. [Disponible a: https://hdl.handle.net/2445/119009]

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