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Article

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Accepted version

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2008-10-28

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/147097

PRL-3 is essentially overexpressed in primary colorectal tumours and associates with tumour aggressiveness

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https://doi.org/10.1038/sj.bjc.6604747

Abstract

Phosphatase PRL-3 has been involved in different types of cancer, especially in metastases from colorectal carcinoma (CRC). In this study, we explored both isoforms of PRL-3 as a biomarker to predict the recurrence of stage IIIB-C CRC. Overexpression of PRL-3 was investigated in primary human colorectal tumours (n=20) and hepatic metastases (n=36) xenografted in nude mice, samples characterised by absence of human non-tumoral cells, showing a high degree of expression in metastases (P=0.001). In 27 cases of matched normal colonic mucosa/primary tumour/hepatic metastases, PRL-3 overexpression occurs in primary tumours vs normal mucosa (P=0.001) and in hepatic metastases vs primary tumours (P=0.045). Besides, our results in a series of 80 stage IIIB-C CRC primary tumours showed that high levels of PRL-3 were an independent predictor of metastasis (P<0.0001; OR: 9.791) in multivariate analysis of a binary logistic regression and that PRL-3 expression tightly correlates with parameters of bad outcome. Moreover, PRL-3 expression associated with poor outcome in univariate (P<0.0001) and multivariate Cox models (hazard ratio: 3.322, 95%, confidence interval: 1.405-7.852, P=0.006). In conclusion, PRL-3 is a good marker of aggressiveness of locally advanced CRS and a promising predictor of distant metastases. Nevertheless, for prognosis purposes, it is imperative to validate the cutoff value of PRL-3 expression in a larger and consecutive series and adjuvant setting.

Subject

Metabolisme, Càncer colorectal, Patologia, Càncer de fetge

Subject (English)

Metabolism, Colorectal cancer, Pathology, Liver cancer

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

MOLLEVÍ, David G., et al. PRL-3 is essentially overexpressed in primary colorectal tumours and associates with tumour aggressiveness. British Journal of Cancer. 2008. Vol. 99, num. 10, pags. 1718-1725. ISSN 0007-0920. [consulted: 12 of August of 2026]. Available at: https://hdl.handle.net/2445/147097

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