Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió acceptadaData de publicació
Tots els drets reservats
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/162957
Low serum diamine oxidase (DAO) activity levels in patients with migraine.
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Histamine intolerance is a disorder in the homeostasis of histamine due to a reduced intestinal degradation of this amine, mainly caused by a deficiency in the enzyme diamine oxidase (DAO). Among the several multifaced symptoms associated with histamine intolerance, headache is one of the most recognised and disabling consequences. The aim of this study was to determine the prevalence of DAO deficiency in patients with a confirmed migraine diagnosis according to the current International Headache Society (IHS) and in non-migraine subjects. DAO activity was assessed in a total of 198 volunteers recruited at the Headache Unit of the Hospital General de Catalunya, 137 in the migraine group and 61 as a control group. DAO enzyme activity in blood samples was determined by ELISA test. Values below 80 HDU/ml (Histamine Degrading Unit/ml) were considered as DAO deficient. Mean value of DAO activity from migraine population (64.5 ±33.5 HDU/ml) was significantly lower (p<0.0001) than that obtained from healthy volunteers (91.9 ± 44.3 HDU/ml). DAO deficiency was more prevalent in migraine patients than in the control group. A high incidence rate of DAO deficiency (87%) was observed in the group of patients with migraine. On the other hand, 44% of non-migranous subjects had levels of DAO activity lower than 80 HDU/ml. Despite the multifactorial etiology of migraine, these results seem to indicate that this enzymatic deficit could be related to the onset of migraine.
Matèries
Matèries (anglès)
Citació
Citació
Izquierdo-Casas Joan, COMAS BASTÉ, Oriol, LATORRE MORATALLA, Mariluz, LORENTE-GASCÓN, Marian, DUELO, Adriana, VIDAL CAROU, Ma. carmen, SOLER-SINGLA, Luis. Low serum diamine oxidase (DAO) activity levels in patients with migraine.. _Journal of Physiology and Biochemistry_. 2017. Vol. 74, núm. 1, pàgs. 93-99. [consulta: 21 de gener de 2026]. ISSN: 1138-7548. [Disponible a: https://hdl.handle.net/2445/162957]