Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/188742
Innovative Non-PrP-Targeted Drug Strategy Designed to Enhance Prion Clearance
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Prion diseases are a group of neurodegenerative disorders characterized by the accumulation of misfolded prion protein (called PrPSc). Although conversion of the cellular prion protein (PrPC) to PrPSc is still not completely understood, most of the therapies developed until now are based on blocking this process. Here, we propose a new drug strategy aimed at clearing prions without any direct interaction with neither PrPC nor PrPSc. Starting from the recent discovery of SERPINA3/SerpinA3n upregulation during prion diseases, we have identified a small molecule, named compound 5 (ARN1468), inhibiting the function of these serpins and effectively reducing prion load in chronically infected cells. Although the low bioavailability of this compound does not allow in vivo studies in prion-infected mice, our strategy emerges as a novel and effective approach to the treatment of prion disease.
Matèries
Matèries (anglès)
Citació
Citació
COLINI BALDESCHI, Arianna, ZATTONI, Marco, VANNI, Silvia, NIKOLIC, Lea, FERRACIN, Chiara, LA SALA, Giuseppina, SUMMA, Maria, BERTORELLI, Rosalia, BERTOZZI, Sine mandrup, GIACHIN, Gabriele, CARLONI, Paolo, BOLOGNESI, Maria laura, DE VIVO, Marco, LEGNAME, Giuseppe. Innovative Non-PrP-Targeted Drug Strategy Designed to Enhance Prion Clearance. _Journal of Medicinal Chemistry_. 2022. Vol. 65, núm. 13, pàgs. 8998-9010. [consulta: 23 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/188742]