Files
Document type
ArticleVersion
Published versionPublication date
Publication license
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/193026
The estructural role of SARS-Cov-2 genetic background on the emergence and scucess of Spike mutations: the case of the Spike A222 mutation
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
The S:A222V point mutation, within the G clade, was characteristic of the 20E (EU1) SARS-CoV-2 variant identified in Spain in early summer 2020. This mutation has since reappeared in the Delta subvariant AY.4.2, raising questions about its specific effect on viral infection. We report combined serological, functional, structural and computational studies character-izing the impact of this mutation. Our results reveal that S:A222V promotes an increased RBD opening and slightly increases ACE2 binding as compared to the parent S:D614G clade. Finally, S:A222V does not reduce sera neutralization capacity, suggesting it does not affect vaccine effectiveness
Subject
Subject (English)
Citation
Citation
GINEX, Tiziana, et al. The estructural role of SARS-Cov-2 genetic background on the emergence and scucess of Spike mutations: the case of the Spike A222 mutation. PLoS Pathogens. 2022. Vol. 18, num. 7. ISSN 1553-7366. [consulted: 16 of June of 2026]. Available at: https://hdl.handle.net/2445/193026