The estructural role of SARS-Cov-2 genetic background on the emergence and scucess of Spike mutations: the case of the Spike A222 mutation

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dc.contributor.authorGinex, Tiziana
dc.contributor.authorMarco-Marín, Clara
dc.contributor.authorWieczor, Miłosz
dc.contributor.authorMata, Carlos P.
dc.contributor.authorKrieger, James
dc.contributor.authorRuiz-Rodriguez, Paula
dc.contributor.authorLópez-Redondo, Maria Luisa
dc.contributor.authorFrancésc-Gómez, Clara
dc.contributor.authorMelero, Roberta
dc.contributor.authorSánchez-Sorzano, Carlos Oscar
dc.contributor.authorMartínez, Marta
dc.contributor.authorGougeard, Nadine
dc.contributor.authorForcada-Nadal, Alicia
dc.contributor.authorZamora-Caballero, Sara
dc.contributor.authorGozalbo-Rovira, Roberto
dc.contributor.authorSanz-Frasquet, Carla
dc.contributor.authorArranz, Rocío
dc.contributor.authorBravo, Jeronimo
dc.contributor.authorRubio, Vicente
dc.contributor.authorMarina, Alberto
dc.contributor.authorGeller, Ron
dc.contributor.authorComas, Iñaki
dc.contributor.authorGil, Carmen
dc.contributor.authorCoscolla, Mireia
dc.contributor.authorOrozco López, Modesto
dc.contributor.authorLlácer, José Luis
dc.contributor.authorCarazo, Jose-Maria
dc.date.accessioned2023-02-03T10:33:43Z
dc.date.available2023-02-03T10:33:43Z
dc.date.issued2022-07-11
dc.date.updated2023-02-03T10:33:43Z
dc.description.abstractThe S:A222V point mutation, within the G clade, was characteristic of the 20E (EU1) SARS-CoV-2 variant identified in Spain in early summer 2020. This mutation has since reappeared in the Delta subvariant AY.4.2, raising questions about its specific effect on viral infection. We report combined serological, functional, structural and computational studies character-izing the impact of this mutation. Our results reveal that S:A222V promotes an increased RBD opening and slightly increases ACE2 binding as compared to the parent S:D614G clade. Finally, S:A222V does not reduce sera neutralization capacity, suggesting it does not affect vaccine effectiveness
dc.format.extent28 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec724866
dc.identifier.issn1553-7366
dc.identifier.urihttps://hdl.handle.net/2445/193026
dc.language.isoeng
dc.publisherPublic Library of Science (PLoS)
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1371/journal.ppat.1010631
dc.relation.ispartofPLoS Pathogens, 2022, vol. 18, num. 7
dc.relation.urihttps://doi.org/10.1371/journal.ppat.1010631
dc.rightscc-by (c) Ginex, Tiziana et al., 2022
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceArticles publicats en revistes (Bioquímica i Biomedicina Molecular)
dc.subject.classificationSARS-CoV-2
dc.subject.classificationInfeccions
dc.subject.classificationMutació (Biologia)
dc.subject.classificationVacunes
dc.subject.otherSARS-CoV-2
dc.subject.otherInfections
dc.subject.otherMutation (Biology)
dc.subject.otherVaccines
dc.titleThe estructural role of SARS-Cov-2 genetic background on the emergence and scucess of Spike mutations: the case of the Spike A222 mutation
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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Articles publicats en revistes (Bioquímica i Biomedicina Molecular)