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The role of genetic variability in the SLC6A4, BDNF and GABRA6 genes in anxiety related traits
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The aims of this study were to test the individual association of the 5-HTT, BDNF, and GABRA6 genes with anxiety-related traits and to explore putative GxG interactions in a healthy sample. Method: A sample of 937 individuals from the general population completed the TCI questionnaire; a subsample of 553 individuals also filled in a brief version of the NEO inventory. The whole sample was genotyped for the 5-HTTLPR polymorphism (5- HTT gene), the Val66Met polymorphism (BDNF gene) and the T1521C polymorphism (GABRA6 gene). Results: Individuals carrying the TTgenotype of the T1512C polymorphism presented slightly higher scores for Harm Avoidance ( HA ) than C allele carriers (F=2.96, p=0.051). In addition, there was a significant GxG interaction on HA between the 5-HTTLPR and Val66Met polymorphisms (F=3.4, p=0.009). Conclusion: GABRA6 emerges as a putative gene may be involved in the variability of HA. The effect of a significant GxG interaction between the 5-HTT and BDNF genes on HA could explain part of the genetic basis underlying anxiety-related traits.
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ARIAS SAMPÉRIZ, Bárbara, et al. The role of genetic variability in the SLC6A4, BDNF and GABRA6 genes in anxiety related traits. Acta Psychiatrica Scandinavica. 2012. Vol. 125, num. 194-202. ISSN 0001-690X. [consulted: 7 of July of 2026]. Available at: https://hdl.handle.net/2445/124884