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The role of genetic variability in the SLC6A4, BDNF and GABRA6 genes in anxiety related traits
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The aims of this study were to test the individual association of the 5-HTT, BDNF, and GABRA6 genes with anxiety-related traits and to explore putative GxG interactions in a healthy sample. Method: A sample of 937 individuals from the general population completed the TCI questionnaire; a subsample of 553 individuals also filled in a brief version of the NEO inventory. The whole sample was genotyped for the 5-HTTLPR polymorphism (5- HTT gene), the Val66Met polymorphism (BDNF gene) and the T1521C polymorphism (GABRA6 gene). Results: Individuals carrying the TTgenotype of the T1512C polymorphism presented slightly higher scores for Harm Avoidance ( HA ) than C allele carriers (F=2.96, p=0.051). In addition, there was a significant GxG interaction on HA between the 5-HTTLPR and Val66Met polymorphisms (F=3.4, p=0.009). Conclusion: GABRA6 emerges as a putative gene may be involved in the variability of HA. The effect of a significant GxG interaction between the 5-HTT and BDNF genes on HA could explain part of the genetic basis underlying anxiety-related traits.
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ARIAS SAMPÉRIZ, Bárbara, AGUILERA, María del carmen, MOYA HIGUERAS, Jorge, SÁIZ MARTÍNEZ, Pilar alejandra, VILLA, H., IBÁÑEZ RIBES, Manuel ignacio, GARCÍA-PORTILLO, M.a., RUIPÉREZ RODRÍGUEZ, María ángeles, BOBES GARCÍA, Julio, ORTET I FABREGAT, Generós, FAÑANÁS SAURA, Lourdes. The role of genetic variability in the SLC6A4, BDNF and GABRA6 genes in anxiety related traits. _Acta Psychiatrica Scandinavica_. 2012. Vol. 125, núm. 194-202. [consulta: 27 de gener de 2026]. ISSN: 0001-690X. [Disponible a: https://hdl.handle.net/2445/124884]