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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/172747
Inherited MC1R variants in patients with melanoma are associated with better survival in women
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Background: Women have a better melanoma prognosis, and fairer skin/hair colour. The presence of inherited MC1R variants has been associated with a better melanoma prognosis, but its interaction with sex is unknown. Objectives: To evaluate the relationship between germline MC1R status and survival, and determine any association with sex. Methods: This was a cohort study including 1341 patients with melanoma from the Melanoma Unit of the Hospital Clinic of Barcelona, between January 1996 and April 2018. We examined known sex‐related prognosis factors as they relate to features of melanoma and evaluated the sex‐specific role of MC1R in overall and melanoma‐specific survival. Hazard ratios (HRs) were calculated using univariate and multivariate Cox logistic regression. Results: Men showed lower overall survival than women (P < 0·001) and the presence of inherited MC1R variants was not associated with better survival in our cohort. However, in women the presence of MC1R variants was associated with better overall survival in the multivariate analysis [HR 0·57, 95% confidence interval (CI) 0·38-0·85; P = 0·006] but not in men [HR 1·26, 95% CI 0·89-1·79; P = 0·185 (P‐value for interaction 0·004)]. Analysis performed for melanoma‐specific survival showed the same level of significance. Conclusions: Inherited MC1R variants are associated with improved overall survival in women with melanoma but not in men. Intrinsic sex‐dependent features can modify the role of specific genes in melanoma prognosis. We believe that survival studies of patients with melanoma should include analysis by sex and MC1R genotype.
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LIRA, F. e., PODLIPNIK, Sebastian, POTRONY MATEU, Míriam, TELL MARTÍ, Gemma, CALBET LLOPART, Neus, BARREIRO CAPURRO, Alicia, CARRERA ÁLVAREZ, Cristina, MALVEHY, J. (josep), PUIG I SARDÀ, Susana. Inherited MC1R variants in patients with melanoma are associated with better survival in women. _British Journal of Dermatology_. 2020. Vol. 182, núm. 1, pàgs. 138-146. [consulta: 23 de gener de 2026]. ISSN: 0007-0963. [Disponible a: https://hdl.handle.net/2445/172747]