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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/49472
Easy introduction of maleimides at different positions of oligonucleotide chains for conjugation purposes
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[2,5-Dimethylfuran]-protected maleimides were placed at both internal positions and the 3'-end of oligonucleotides making use of solid-phase synthesis procedures. A new phosphoramidite derivative and a new solid support incorporating the protected maleimide moiety were prepared for this purpose. In all cases maleimide deprotection (retro-Diels-Alder reaction) followed by reaction with thiol-containing compounds afforded the target conjugate.
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SÁNCHEZ-MOYA, Albert, PEDROSO MULLER, Enrique and GRANDAS SAGARRA, Anna. Easy introduction of maleimides at different positions of oligonucleotide chains for conjugation purposes. Organic & Biomolecular Chemistry. 2012. Vol. 10, num. 42, pags. 8478-8483. ISSN 1477-0520. [consulted: 12 of October of 2026]. Available at: https://hdl.handle.net/2445/49472