Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Files

556529.pdf (124.91 KB)

Document type

Article

Version

Published version

Publication date

2008-02-01

All rights reserved

Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/48944

Adverse side effects of statins in the oral cavity

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

http://hdl.handle.net/2445/117363

Abstract

Increased plasma levels of cholesterol are high risk factors of cardiovascular disease. Statins are drugs that inhibit cholesterol synthesis at both pancreatic and extrahepathic levels, being the treatment of choice for hypercholesterolemia. Objective: To analyze the side effects of statins in the mouth cavity, and to analyze the symptoms after interruption of the treatment. Design: Observational study, preliminary. Material and methods: Patients aged 50-70, diagnosed with hypercholesterolemia and undergoing treatment with statins, referred from their primary care physician to the dentist"s office. Anamnesis over oral symptoms was performed in the first visit. Statin treatment was discontinued, followed by lab tests and control visits seven and fifteen days later. We monitored the improvement and/or remission of oral symptoms. Statin treatment was resumed, sending out a report of the patient evolution to the PCP. Symptoms were registered in sheet specially designed for the study. Exclusion criteria: patient refusal, use of drugs for dry mouth treatment, Sjögren"s syndrome. Results: n=26 patients. Dry mouth patients: improvement in 17 out of 23 patients (88.5%). Itchiness: 6 out of 15 cases improved (57.7%). Bitterness: improvement in 13 out of 14 patients (53.8%). Cough: improvement in 11 out of 12 patients (46.1%). Discussion: A high percentage of oral symptoms are associated to treatment with statins. There is a marked improvement after temporary interruption of the treatment. Little is known regarding the side effects of oral treatment with statins. This preliminary study includes a relatively small number of patients. The design of experimental treatments will be required to establish a true correlation between statin treatment and oral symptoms

Description

Podeu consultar la versió en castellà a http://hdl.handle.net/2445/117363

Subject

Hipercolesterolèmia, Malalties de la boca, Símptomes, Efectes secundaris dels medicaments

Subject (English)

Hypercholesteremia, Mouth diseases, Symptoms, Drug side effects

Citation

Collections

Articles publicats en revistes (Odontoestomatologia)

Citation

PASCUAL CRUZ, Montserrat, et al. Adverse side effects of statins in the oral cavity. Medicina Oral. Patología Oral y Cirugia Bucal. Vol.  2008, num. 13, pags. 2. ISSN 1698-4447. [consulted: 8 of August of 2026]. Available at: https://hdl.handle.net/2445/48944

Export metadata

JSON - METS

Share record