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2016-10-05

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cc-by (c) Garcia-Salcedo, Jose Alberto et al., 2016
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/232601

Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery

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The adaptation of existing antimalarial nanocarriers to new Plasmodium stages, drugs, targeting molecules, or encapsulating structures is a strategy that can provide new nanotechnology-based, cost-efficient therapies against malaria. We have explored the modification of different liposome prototypes that had been developed in our group for the targeted delivery of antimalarial drugs to Plasmodium-infected red blood cells (pRBCs). These new models include: (i) immunoliposome-mediated release of new lipid-based antimalarials; (ii) liposomes targeted to pRBCs with covalently linked heparin to reduce anticoagulation risks; (iii) adaptation of heparin to pRBC targeting of chitosan nanoparticles; (iv) use of heparin for the targeting of Plasmodium stages in the mosquito vector; and (v) use of the non-anticoagulant glycosaminoglycan chondroitin 4-sulfate as a heparin surrogate for pRBC targeting. The results presented indicate that the tuning of existing nanovessels to new malaria-related targets is a valid low-cost alternative to the de novo development of targeted nanosystems.

Recurs relacionat

https://doi.org/10.1016/j.nano.2016.09.010

Matèries

Nanomedicina, Malària, Dispositius d'administració de medicaments

Matèries (anglès)

Nanomedicine, Malaria, Drug delivery devices

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Col·leccions

Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (Centres Científics i Tecnològics de la Universitat de Barcelona (CCiTUB))
Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB))
Articles publicats en revistes (ISGlobal)

Citació

GARCIA-SALCEDO, Jose Alberto, et al. Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery. Nanomedicine: Nanotechnology. Biology and Medicine. Vol.  2016, num. 13, pags. 2. ISSN 1549-9634. [consulted: 5 of November of 2026]. Available at: https://hdl.handle.net/2445/232601

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