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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/124688
Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.
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The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens.
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PALACÍN, Arantxa, GÓMEZ CASADO, Cristina, RIVAS, Luis a., AGUIRRE, Jacobo, TORDESILLAS, Leticia, BARTRA TOMÀS, Joan, BLANCO, Carlos, CARRILLO, Teresa, CUESTA HERRANZ, Javier, FRUTOS, Consolación de, GARCÍA ÁLVAREZ-EIRE, Genoveva, FERNÁNDEZ, Francisco j., GAMBOA, Pedro, MUÑOZ, Rosa, SÁNCHEZ-MONGE, Rosa, SIRVENT, Sofía, TORRES, María j., VARELA LOSADA, Susana, RODRÍGUEZ, Rosalía, PARRO, Victor, BLANCA, Miguel, SALCEDO, Gabriel, DÍAZ PERALES, Araceli. Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.. _PLoS One_. 2012. Vol. 7, núm. 12, pàgs. e50799. [consulta: 23 de gener de 2026]. ISSN: 1932-6203. [Disponible a: https://hdl.handle.net/2445/124688]