Myeloid cell networks govern re-establishment of original immune landscapes in recurrent ovarian cancer

Vista senzilla d'ítem
dc.contributor.authorGhisoni, Eleonora
dc.contributor.authorBenedetti, Fabrizio
dc.contributor.authorMinasyan, Aspram
dc.contributor.authorDesbuisson, Mathieu
dc.contributor.authorCunnea, Paula
dc.contributor.authorGrimm, Alizée J.
dc.contributor.authorFahr, Noémie
dc.contributor.authorCapt, Charlotte
dc.contributor.authorRayroux, Nicolas
dc.contributor.authorCarlo, Flavia de
dc.contributor.authorGulhan, Doga C.
dc.contributor.authorDagher, Julien
dc.contributor.authorBarras, David
dc.contributor.authorMorotti, Matteo
dc.contributor.authorMarín Jiménez, Juan A.
dc.contributor.authorStewen Chap, Bovannak
dc.contributor.authorSantoro, Tania
dc.contributor.authorSpagnol, Giulia
dc.contributor.authorFleury, Mapi
dc.contributor.authorFortis, Katerina
dc.contributor.authorDorier, Julien
dc.contributor.authorTownsend, Mary K.
dc.contributor.authorTissot, Stephanie
dc.contributor.authorRusakiewicz, Sylvie
dc.contributor.authorFerreira, Humberto J.
dc.contributor.authorKraemer, Anne I.
dc.contributor.authorBassani Stenberg, Michal
dc.contributor.authorSwisher, Elizabeth M.
dc.contributor.authorKandalaft, Lana A.
dc.contributor.authorMastroyannis, Spyridon A.
dc.contributor.authorMontone, Kathleen T.
dc.contributor.authorPowell, Daniel J.
dc.contributor.authorBanerjee, Susana
dc.contributor.authorTerry, Kathryn L.
dc.contributor.authorTworoger, Shelley S.
dc.contributor.authorPittet, Mikaël J.
dc.contributor.authorTanyi, Janos L.
dc.contributor.authorCoukos, George
dc.contributor.authorMerritt, Melissa A.
dc.contributor.authorFotopoulou, Christina
dc.contributor.authorConejo García, José R.
dc.contributor.authorDangaj Laniti, Denarda
dc.date.accessioned2025-09-23T07:42:44Z
dc.date.available2025-09-23T07:42:44Z
dc.date.issued2025-07-31
dc.date.updated2025-09-22T10:08:31Z
dc.description.abstractImmunotherapy has shown limited success in recurrent ovarian cancer (OC), with prognostic insights largely derived from treatment-naive tumors. We analyzed 697 tumor samples (566 primary and 131 recurrent) from 595 OC patients across five independent cohorts, capturing tumor-infiltrating lymphocytes (TILs) heterogeneity and identifying four immune phenotypes linked to prognosis and TIL:myeloid networks driving malignant progression. We found that in preclinical mouse models, mirroring inflamed human OCs, the recurrent Brca1mut tumors maintained activated TILs:dendritic cells (DCs) niches but evaded immune control through upregulation of COX/PGE2 signaling. Conversely, recurrent Brca1wt tumors displayed loss of TILs:DCs niches and accumulated immunosuppressive tumor microenvironment (TME) networks featuring Trem2/ ApoEhigh tumor associated macrophages (TAMs) and Nduf4l2high/Galectin3high malignant states. Recurrent tumors recapitulate the immunogenic landscapes of original cancers. Our findings reveal BRCA-dependent TIL:myeloid crosstalk as key to persistent immunogenicity in recurrent OC and propose new targets to enhance chemotherapy efficacy.
dc.format.extent30 p.
dc.format.mimetypeapplication/pdf
dc.identifier.issn1878-3686
dc.identifier.pmid40749672
dc.identifier.urihttps://hdl.handle.net/2445/223347
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1016/j.ccell.2025.07.005
dc.relation.ispartofCancer Cell, 2025, vol. 43, num. 8, p. 1568-1586
dc.relation.urihttps://doi.org/10.1016/j.ccell.2025.07.005
dc.rightscc-by (c) Ghisoni, Eleonora et al., 2025
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.sourceArticles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
dc.subject.classificationCàncer d'ovari
dc.subject.classificationSistema immunitari
dc.subject.otherOvarian cancer
dc.subject.otherImmune system
dc.titleMyeloid cell networks govern re-establishment of original immune landscapes in recurrent ovarian cancer
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

Fitxers

Paquet original

Mostrant 1 - 1 de 1
Miniatura
Nom:
PIIS1535610825002764.pdf
Mida:
10.17 MB
Format:
Adobe Portable Document Format
Descarregar

Col·leccions

Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))