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s41598-021-91055-z.pdf (890.42 KB)

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2021-06-01

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cc by (c) Prieto Peña, Diana et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/178993

BAFF, APRIL and BAFFR on the pathogenesis of Immunoglobulin-A vasculitis

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https://doi.org/10.1038/s41598-021-91055-z

Resum

BAFF, APRIL and BAFF-R are key proteins involved in the development of B-lymphocytes and autoimmunity. Additionally, BAFF, APRIL and BAFFR polymorphisms were associated with immune-mediated conditions, being BAFF GCTGT>A a shared insertion-deletion genetic variant for several autoimmune diseases. Accordingly, we assessed whether BAFF, APRIL and BAFFR represent novel genetic risk factors for Immunoglobulin-A vasculitis (IgAV), a predominantly B-lymphocyte inflammatory condition. BAFF rs374039502, which colocalizes with BAFF GCTGT>A, and two tag variants within APRIL (rs11552708 and rs6608) and BAFFR (rs7290134 and rs77874543) were genotyped in 386 Caucasian IgAV patients and 806 matched healthy controls. No genotypes or alleles differences were observed between IgAV patients and controls when BAFF, APRIL and BAFFR variants were analysed independently. Likewise, no statistically significant differences were found in the genotype and allele frequencies of BAFF, APRIL or BAFFR when IgAV patients were stratified according to the age at disease onset or to the presence/absence of gastrointestinal (GI) or renal manifestations. Similar results were disclosed when APRIL and BAFFR haplotypes were compared between IgAV patients and controls and between IgAV patients stratified according to the clinical characteristics mentioned above. Our results suggest that BAFF, APRIL and BAFFR do not contribute to the genetic network underlying IgAV.

Matèries

Immunoglobulines, Vasculitis, Malalties autoimmunitàries

Matèries (anglès)

Immunoglobulins, Vasculitis, Autoimmune diseases

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
<b>Publicacions de projectes de recerca finançats per la UE</b>

Citació

PRIETO PEÑA, Diana, GENRE, Fernanda, REMUZGO MARTÍNEZ, Sara, PULITO CUETO, Verónica, ATIENZA MATEO, Belén, LLORCA, Javier, SEVILLA PÉREZ, Belén, ORTEGO CENTENO, Norberto, LERA GÓMEZ, Leticia, LEONARDO, María teresa, PEÑALBA, Ana, NARVÁEZ GARCÍA, Francisco javier, MARTÍN PENAGOS, Luis, RODRIGO, Emilio, MIRANDA FILLOY, José a., CAMINAL MONTERO, Luis, COLLADO, Paz, SÁNCHEZ PÉREZ, Javier, ARGILA, Diego de, RUBIO, Esteban, LUQUE, Manuel león, BLANCO MADRIGAL, Juan maría, GALÍNDEZ AGIRREGOIKOA, Eva, GUALILLO, Oreste, MARTÍN, Javier, CASTAÑEDA, Santos, BLANCO, Ricardo, GONZÁLEZ GAY, Miguel a., LÓPEZ MEJÍAS, Raquel. BAFF, APRIL and BAFFR on the pathogenesis of Immunoglobulin-A vasculitis. _Scientific Reports_. 2021. Vol. 11, núm. 11510. [consulta: 25 de febrer de 2026]. ISSN: 2045-2322. [Disponible a: https://hdl.handle.net/2445/178993]

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