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healthcare-11-00179.pdf (521.53 KB)

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2023-01-06

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cc by (c) Pérez Martín, Hipólito et al., 2023
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/192811

Variation in Nicotine Metabolization According to Biological Factors and Type of Nicotine Consumer

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https://doi.org/10.3390/healthcare11020179

Abstract

This study aims to describe the nicotine metabolite ratio among tobacco smokers and electronic cigarette (e-cigarette) users and nonusers. We analyzed pooled data from a longitudinal and a cross-sectional study of the adult population from the city of Barcelona. The final sample included information on 166 smokers, 164 e-cigarettes users with nicotine, 41 e-cigarette users without nicotine, 95 dual users (users of both products), and 508 nonusers. We used log-linear models to control for the potential confounding effect of the daily number of cigarettes smoked. Salivary nicotine metabolic rate assessment included the rate of nicotine metabolism (cotinine/nicotine) and the nicotine metabolite ratio (trans-3′-hydroxycotinine/cotinine). Exclusive users of e-cigarette without nicotine have the lowest rate of nicotine metabolism (Geometric mean: 0.08, p-values < 0.001) while cigarette smokers have the highest (Geometric mean: 2.08, p-values < 0.001). Nonusers have lower nicotine metabolic rate than cigarette smokers (Geometric means: 0.23 vs. 0.18, p-value < 0.05). Younger individuals (18–44 years) have a higher rate of nicotine metabolism than older individuals (45–64 years and 65–89) (Geometric means: 0.53 vs. 0.42 and 0.31, respectively, p-values < 0.01) and individuals with lower body mass index (21–25 kg/m2) have a higher rate of nicotine metabolism than the rest (26–30 kg/m2 and 31–60 kg/m2) (Geometric means: 0.52 vs. 0.35 and 0.36, respectively-values < 0.01). Nicotine metabolic rates are useful biomarkers when reporting smoking status and biological differences between individuals.

Subject

Nicotina, Metabolisme, Cigarretes electròniques, Hàbit de fumar

Subject (English)

Nicotine, Metabolism, Electronic cigarettes, Smoking

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

PÉREZ MARTÍN, Hipólito, et al. Variation in Nicotine Metabolization According to Biological Factors and Type of Nicotine Consumer. Healthcare. 2023. Vol. 11, num. 2, pags. 179. ISSN 2227-9032. [consulted: 15 of August of 2026]. Available at: https://hdl.handle.net/2445/192811

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