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2007-01

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/160425

Facile synthesis of azocino[4,3-b]indoles by ring-closing metathesis

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Abstract

The azocino[4,3-b]indole system, tricyclic substructure of the indole alkaloids apparicine and ervaticine, is efficiently assembled by ring-closing metathesis of 2-allyl-3-(allylaminomethyl)indoles. The metathesis sites are introduced into the indole nucleus by reductive amination of a 3-formyl derivative with allylamine, followed by a-lithiation with subsequent electrophilic trapping with acrolein.

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https://doi.org/10.1016/j.tet.2006.11.043

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Alcaloides, Metàtesi (Química), Síntesi orgànica

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Alkaloids, Metathesis (Chemistry), Organic synthesis

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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BENNASAR FÈLIX, M. Lluïsa, et al. Facile synthesis of azocino[4,3-b]indoles by ring-closing metathesis. Tetrahedron. 2007. Vol. 63, num. 4, pags. 861-866. ISSN 0040-4020. [consulted: 11 of October of 2026]. Available at: https://hdl.handle.net/2445/160425

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