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fnut-10-1034481.pdf (305.9 KB)

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2023-01-27

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cc by (c) Llop Talaverón, Josep Manuel et al., 2023
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/197200

Inflammatory processes involved in the alteration of liver function biomarkers in adult hospitalized patients treated with parenteral nutrition

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https://doi.org/10.3389/fnut.2023.1034481

Resum

IntroductionLiver damage has been associated with the accumulation of phytosterols (PS) in patients treated with parenteral nutrition (PN). We aimed to study the association of inflammatory markers with liver function biomarker (LFB) alterations in patients treated with PN containing PS. Materials and methodsProspective observational study. Simple linear and stepwise multiple linear regression tests and interactions were performed. ResultsNineteen patients were included. In the multivariable model, determinations based on LFBs as dependent and phytosterols (and their fractions) as independent variables showed an association between increases in gamma-glutamyltransferase (GGT) and lanosterol (p < 0.001), stigmasterol (p < 0.001), interleukin-10 (IL-10) x total phytosterols (Phyt) (p < 0.009), tumor necrosis factor-alpha (TNF-alpha) x Phyt (p < 0.002), IL-10 x sitosterol (p < 0.002), TNF-alpha x sitosterol (p < 0.001), IL-10 x campesterol (p < 0.033), IL-10 (p < 0.006 and p < 0.015), TNF-alpha (p < 0.048 and p < 0.027). Increases in alanine aminotransferase (ALT) were associated with Phyt (p < 0.006), lanosterol (p < 0.016), C-reactive protein (CRP) x campesterol (p < 0.001), interleukin-6 (IL-6) x stigmasterol (p < 0.030), CRP (p < 0.08), and IL-6 (p < 0.042). Alkaline phosphatase (AP) increases were associated with CRP (p < 0.002). DiscussionInflammation in the presence of plasmatic PS seems to have a synergistic effect in impairing liver function, mainly altering GGT but also ALT.

Matèries

Fetge, Alimentació parenteral

Matèries (anglès)

Parenteral feeding, Liver

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

LLOP TALAVERÓN, Josep Manuel, et al. Inflammatory processes involved in the alteration of liver function biomarkers in adult hospitalized patients treated with parenteral nutrition. Frontiers in Nutrition. 2023. Vol. 10. ISSN 2296-861X. [consulted: 3 of August of 2026]. Available at: https://hdl.handle.net/2445/197200

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