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Article

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Accepted version

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2012-03

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/164192

Cyclocondensation reactions of 2-acyl-3-indoleacetic acid derivatives with phenylglycinol. Enantioselective synthesis of 1-substituted tetrahydro-b-carboline alkaloids

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https://doi.org/10.1002/ejoc.201101718

Abstract

Cyclocondensation reactions between a variety of 2‐acyl‐3‐indoleacetic acid derivatives and (R )‐phenylglycinol were studied. Successful results were obtained from N ‐alkyl keto acid derivatives. The resulting tetracyclic lactams provide straightforward access to enantiopure 1‐substituted tetrahydro‐β‐carboline alkaloids.

Subject

Síntesi asimètrica, Alcaloides, Lactames

Subject (English)

Asymmetric synthesis, Alkaloids, Lactams

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

Citation

AMAT TUSÓN, Mercedes, et al. Cyclocondensation reactions of 2-acyl-3-indoleacetic acid derivatives with phenylglycinol. Enantioselective synthesis of 1-substituted tetrahydro-b-carboline alkaloids. European Journal of Organic Chemistry. 2012. Vol. 2012, num. 9, pags. 1835-1842. ISSN 1434-193X. [consulted: 9 of August of 2026]. Available at: https://hdl.handle.net/2445/164192

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