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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/219360
Cobalt(III)-py(2)en systems as potential carriers of beta-ketoester-based ligands
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Two cobalt(III) complexes containing different β-ketoesters, namely [CoIII(L1)(py2en)](ClO4)2·H2O (1) and [CoIII(L2)(py2en)](ClO4)2 (2) (py2en = N,N′-bis(pyridin-2-ylmethyl)ethylenediamine; L1− = methylacetoacetate; L2− = ethyl 4-chloroacetoacetate) have been prepared and investigated as prototypes of bioreductive prodrugs. The presence of β-ketoester and py2en ligands in 1 and 2, as well as the perchlorate counterions, was supported by IR spectroscopy and CHN elemental analysis. The composition molecular structure of both complexes was confirmed by NMR spectroscopy and ESI mass spectrometry. Structural information was also obtained for 2 via X-ray diffraction analysis. The redox properties indicate that 1 and 2 are suitable for reduction under biological conditions. Investigation of DNA-interacting suggest that 1 and 2 bind DNA via electrostatic forces. Both complexes may be employed as possible platforms for the delivery of biologically active compounds, since their reaction with ascorbic acid in PBS at pH 6.2 and 7.4 at 37°C results in the release of the β-ketoester ligands upon Co(III)/Co(II) reduction.
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PALMEIRA-MELLO, Marcos V., et al. Cobalt(III)-py(2)en systems as potential carriers of beta-ketoester-based ligands. Journal of Inorganic Biochemistry. 2023. Vol. 248, num. 112345. ISSN 0162-0134. [consulted: 17 of August of 2026]. Available at: https://hdl.handle.net/2445/219360