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2022-08-16

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cc by (c) Climent Cantó, Paula et al., 2022
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/188925

Oxidative Stress Is Associated with Overgrowth in Drosophila l(3)mbt Mutant Imaginal Discs

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https://doi.org/10.3390/cells11162542

Abstract

The loss-of-function conditions for an l(3)malignant brain tumour (l(3)mbt) in larvae reared at 29 degrees C results in malignant brain tumours and hyperplastic imaginal discs. Unlike the former that have been extensively characterised, little is known about the latter. Here we report the results of a study of the hyperplastic l(3)mbt mutant wing imaginal discs. We identify the l(3)mbt wing disc tumour transcriptome and find it to include genes involved in reactive oxygen species (ROS) metabolism. Furthermore, we show the presence of oxidative stress in l(3)mbt hyperplastic discs, even in apoptosis-blocked conditions, but not in l(3)mbt brain tumours. We also find that chemically blocking oxidative stress in l(3)mbt wing discs reduces the incidence of wing disc overgrowths. Our results reveal the involvement of oxidative stress in l(3)mbt wing discs hyperplastic growth.

Subject

Drosòfila, Estrès oxidatiu, Hiperplàsia suprarenal congènita, Càncer, Tumors

Subject (English)

Drosophila, Oxidative stress, Congenital adrenal hyperplasia, Cancer, Tumors

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Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Institut de Biomedicina (IBUB))
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

Citation

CLIMENT-CANTÓ, Paula, et al. Oxidative Stress Is Associated with Overgrowth in Drosophila l(3)mbt Mutant Imaginal Discs. Cells. 2022. Vol. 11, num. 16, pags. 2542. ISSN 2073-4409. [consulted: 16 of August of 2026]. Available at: https://hdl.handle.net/2445/188925

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