Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/167363
New Treatment for psoriasis: therapeutic efficiency in patients and antiinflammatory effect in vitro
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Background: Psoriasis is a worldwide chronic inflammatory disease that is increasingly being considered as a systemic disorder. Antioxidant and anti-inflammatory molecules have been revealed as potential adjuvants for traditional therapies.Objectives: To evaluate the antiinflammatory action of selected antioxidant molecules and their beneficial effect as combination therapy in psoriatic patients. Materials & Methods: Thirty-five patients with mild (five), moderate (nine) and severe (twenty one) psoriasis were selected and treated with EP2311454 treatment. PASI, BSA and DLQI assessed the severity of psoriasis and the impact on quality of life. The antiinflammatory effect was tested in IFN-γ stimulated Raw264.7 macrophages that express human PPARG.Results: The combined use in vitro of several EP2311454 components exerts a synergistic inhibitory effect on the expression of the proinflammatory mediators Cox2, Nos2 and Cxcl9. Clinically, more than 80% reduction in DLQI levels is observed after treatment, and 100% of severe patients achieved PASI 75 and significant reduction of BSA levels after 15 days of treatment.Conclusion: EP2311454 treatment, composed by antioxidant molecules, proved to be antiinflammatory in vitro and showed efficacy in patients with mild to severe psoriasis, as demonstrated by a significant decrease in PASI, BSA and DLQI levels.
Matèries
Matèries (anglès)
Citació
Citació
UMBERT MILLET, Ignacio, MÁRQUEZ-KISINOUSKY, Leonardo, FARRERA, Consol, VALLS, Jordi, VALLEDOR FERNÁNDEZ, Annabel, FERNÁNDEZ-FERNÁNDEZ, Laura. New Treatment for psoriasis: therapeutic efficiency in patients and antiinflammatory effect in vitro. _JOJ Dermatology & Cosmetics_. 2020. Vol. 3, núm. 1. [consulta: 23 de gener de 2026]. ISSN: 2689-4610. [Disponible a: https://hdl.handle.net/2445/167363]