Files
Document type
ArticleVersion
Published versionPublication date
All rights reserved
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/161438
Microstructural white matter changes in metabolic syndrome: A diffusion tensor imaging study
Journal Title
Director/Tutor
Additional contribution
Journal ISSN
Volume Title
Abstract
BACKGROUND: Although metabolic syndrome is associated with cardiovascular disease and stroke, limited information is available on specific brain damage in patients with this syndrome. We investigated the relationship of the syndrome with white matter (WM) alteration using a voxel-based approach with diffusion tensor imaging (DTI). METHODS: We compared fractional anisotropy (FA) and apparent diffusion coefficient (ADC) measurements of DTI in 19 patients with metabolic syndrome aged between 50 and 80 years and 19 age-matched controls without any vascular risk factors for the syndrome. RESULTS: Patients with metabolic syndrome showed an anterior-posterior pattern of deterioration in WM with reduced FA and increased ADC values compared with controls. WM changes were not related to any isolated vascular risk factor. CONCLUSION: Although the mechanism of this damage is not clear, the results indicate microstructural white matter alterations in patients with metabolic syndrome, mainly involving the frontal lobe.
Related resource
Subject (English)
Citation
Citation
SEGURA I FÀBREGAS, Bàrbara, et al. Microstructural white matter changes in metabolic syndrome: A diffusion tensor imaging study. Neurology. 2009. Vol. 73, num. 6, pags. 438-444. ISSN 0028-3878. [consulted: 17 of October of 2026]. Available at: https://hdl.handle.net/2445/161438