Document type
ArticleVersion
Accepted versionPublication date
All rights reserved
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/126452
Chronotropic incompetence predicts mortality in severe obstructive pulmonary disease
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
We evaluated the prevalence of chronotropic incompetence (CI), a marker of autonomic dysfunction, and its prognostic value in patients with chronic obstructive pulmonary disease (COPD). We performed a retrospective analysis of 449 patients with severe COPD who underwent a cardiopulmonary exercise test, after excluding patients with lung volume reduction surgery, left ventricular dysfunction and those not in sinus rhythm. CI was defined as percent predicted heart rate reserve (%HRR). Events were defined as death or lung transplant during a median follow-up of 68 months. Median age was 61 years; median percent predicted forced expiratory volume in one second (%FEV1) of 25% and median %HRR of 33%. The hazard ratio for an event in the lowest quartile of %HRR, taking the highest quartile as reference, was of 3.2 (95% confidence interval: 2.1-4.8; p < 0.001). In a multivariate regression model, %HRR was an independent predictor of events. In conclusion, Cl was an independent and powerful outcome predictor in patients with severe COPD. (C) 2013 Elsevier B.V. All rights reserved.
Subject (English)
Citation
Citation
GONZÁLEZ-COSTELLO, José, et al. Chronotropic incompetence predicts mortality in severe obstructive pulmonary disease. Respiratory Physiology & Neurobiology. 2013. Vol. 188, num. 2, pags. 113-118. [consulted: 16 of August of 2026]. Available at: https://hdl.handle.net/2445/126452