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2012-07-20

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cc-by (c) Franquesa, M. et al., 2012
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/34516

Immunomodulatory effect of mesenchymal stem cells on B cells

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Recurs relacionat

http://dx.doi.org/10.3389/fimmu.2012.00212

Resum

The research on T cell immunosuppression therapies has attracted most of the attention in clinical transplantation. However, B cells and humoral immune responses are increasingly acknowledged as crucial mediators of chronic allograft rejection. Indeed, humoral immune responses can lead to renal allograft rejection even in patients whose cell-mediated immune responses are well controlled. On the other hand, newly studied B cell subsets with regulatory effects have been linked to tolerance achievement in transplantation. Better understanding of the regulatory and effector B cell responses may therefore lead to new therapeutic approaches. Mesenchymal stem cells (MSC) are arising as a potent therapeutic tool in transplantation due to their regenerative and immunomodulatory properties.The research on MSCs has mainly focused on their effects onT cells and although data regarding the modulatory effects of MSCs on alloantigen-specific humoral response in humans is scarce, it has been demonstrated that MSCs significantly affect B cell functioning. In the present review we will analyze and discuss the results in this field.

Matèries

Trasplantament d'òrgans, Immunosupressió

Matèries (anglès)

Transplantation of organs, Immunosuppression

Citació

Col·leccions

Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

FRANQUESA, Marcella, et al. Immunomodulatory effect of mesenchymal stem cells on B cells. Frontiers in Immunology. 2012. Vol. 3, num. 212. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/34516

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