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2023-04-21

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cc-by-nc-nd (c) Rojo, Pep, et al., 2023
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/218806

Bulky P-stereogenic ligands. A success story in asymmetric catalysis

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https://doi.org/10.1016/j.ccr.2023.215192

Abstract

Since the development of BisP* ligand by Imamoto, P-stereogenic phosphines bearing a bulky tert-butyl group and a smaller alkyl group have demonstrated extraordinary proficiency in a wide range of asymmetric processes. Over time, this class of ligands has brought about the introduction of more rigid backbones, the three-hindered quadrant concept, and the substitution of the tert-butyl group by adamantyl. The tert-butyl methyl fragment has also been introduced in phosphino-oxazoline-type ligands, and chemists in the industrial sector have also contributed to the evolution of this class of ligands by reporting the first successful P-stereogenic Buchwald-type monophosphines for asymmetric coupling reactions. The present review covers the synthesis and applications of bulky P-stereogenic phosphines that have been developed since the advent of BisP* in the late 1990s, with a special emphasis on ligands that have been successfully applied in asymmetric catalysis.

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Oxidació, Catàlisi, Quiralitat

Subject (English)

Oxidation, Catalysis, Chirality

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Articles publicats en revistes (Química Inorgànica i Orgànica)
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

Citation

ROJO, Pep, RIERA I ESCALÉ, Antoni and VERDAGUER I ESPAULELLA, Xavier. Bulky P-stereogenic ligands. A success story in asymmetric catalysis. Coordination Chemistry Reviews. 2023. Vol. 489, num. 215192. ISSN 0010-8545. [consulted: 10 of August of 2026]. Available at: https://hdl.handle.net/2445/218806

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