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2020-11-12

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cc-by (c) Trapero, Carla et al., 2020
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/183725

Purinergic signaling in endometriosis-associated pain

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https://doi.org/10.3390/ijms21228512

Abstract

Endometriosis is an estrogen-dependent gynecological disease, with an associated chronic inflammatory component, characterized by the presence of endometrial tissue outside the uterine cavity. Its predominant symptom is pain, a condition notably altering the quality of life of women with the disease. This review is intended to exhaustively gather current knowledge on purinergic signaling in endometriosis-associated pain. Altered extracellular ATP hydrolysis, due to changes in ectonucleotidase activity, has been reported in endometriosis; the resulting accumulation of ATP in the endometriotic microenvironment points to sustained activation of nucleotide receptors (P2 receptors) capable of generating a persistent pain message. P2X3 receptor, expressed in sensory neurons, mediates nociceptive, neuropathic, and inflammatory pain, and is enrolled in endometriosis-related pain. Pharmacological inhibition of P2X3 receptor is under evaluation as a pain relief treatment for women with endometriosis. The role of other ATP receptors is also discussed here, e.g., P2X4 and P2X7 receptors, which are involved in inflammatory cell-nerve and microglia-nerve crosstalk, and therefore in inflammatory and neuropathic pain. Adenosine receptors (P1 receptors), by contrast, mainly play antinociceptive and anti-inflammatory roles. Purinome-targeted drugs, including nucleotide receptors and metabolizing enzymes, are potential non-hormonal therapeutic tools for the pharmacological management of endometriosis-related pain.

Subject

Endometriosi, Adenosina, Dolor, Inflamació

Subject (English)

Endometriosis, Adenosine, Pain, Inflammation

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Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

TRAPERO, Carla and MARTÍN SATUÉ, Mireia. Purinergic signaling in endometriosis-associated pain. International Journal of Molecular Sciences. 2020. Vol. 21, num. 22, pags. 8512. ISSN 1661-6596. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/183725

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