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2016-08-18

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cc by (c) López Mejías et al., 2016
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/126821

Influence of elevated-CRP levelrelated polymorphisms in nonrheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis

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https://doi.org/10.1038/srep31979

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Association between elevated C-reactive protein (CRP) serum levels and subclinical atherosclerosis and cardiovascular (CV) events was described in rheumatoid arthritis (RA). CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 exert an influence on elevated CRP serum levels in non-rheumatic Caucasians. Consequently, we evaluated the potential role of these genes in the development of CV events and subclinical atherosclerosis in RA patients. Three tag CRP polymorphisms and HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were genotyped in 2,313 Spanish patients by TaqMan. Subclinical atherosclerosis was determined in 1,298 of them by carotid ultrasonography (by assessment of carotid intima-media thickness-cIMT-and presence/absence of carotid plaques). CRP serum levels at diagnosis and at the time of carotid ultrasonography were measured in 1,662 and 1,193 patients, respectively, by immunoturbidimetry. Interestingly, a relationship between CRP and CRP serum levels at diagnosis and at the time of the carotid ultrasonography was disclosed. However, no statistically significant differences were found when CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were evaluated according to the presence/absence of CV events, carotid plaques and cIMT after adjustment. Our results do not confirm an association between these genes and CV disease in RA.

Matèries

Artritis reumatoide, Aterosclerosi

Matèries (anglès)

Rheumatoid arthritis, Atherosclerosis

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

LÓPEZ MEJÍAS, Raquel, GENRE, Fernanda, REMUZGO MARTÍNEZ, Sara, GONZÁLEZ JUANATEY, Carlos, ROBUSTILLO VILLARINO, Montserrat, LLORCA DÍAZ, Javier, CORRALES, Alfonso, VICENTE, Esther f., MIRANDA-FILLOY, José a., MAGRO CHECA, Cesar, TEJERA SEGURA, Beatriz, RAMÍREZ HUARANGA, Marco a., PINA, Trinitario, BLANCO, Ricardo, ALEGRE-SANCHO, Juan josé, RAYA, Enrique, MIJARES, Verónica, UBILLA, Begoña, MÍNGUEZ SANCHEZ, María d., GÓMEZ VAQUERO, Carmen, BALSA, Alejandro, PASCUAL-SALCEDO, Dora, LÓPEZ LONGO, Francisco j., CARREIRA, Patricia, GONZÁLEZ ÁLVARO, Isidoro, RODRÍGUEZ-RODRÍGUEZ, Luis, FERNÁNDEZ GUTIÉRREZ, Benjamín, FERRAZ AMARO, Iván, CASTAÑEDA, Santos, MARTÍN, Javier, GONZÁLEZ-GAY, Miguel a.. Influence of elevated-CRP levelrelated polymorphisms in nonrheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis. _Scientific Reports_. 2016. Vol. 6. [consulta: 25 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/126821]

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