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Article

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2019-05-09

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/147235

Synthetic Photoswitchable Neurotransmitters Based on Bridged Azobenzenes

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https://doi.org/10.1021/acs.orglett.9b01222

Abstract

Photoswitchable neurotransmitters of ionotropic kainate receptors were synthesized by tethering a glutamate moiety to disubstituted C2-bridged azobenzenes, which were prepared through a novel methodology that allows access to diazocines with higher yields and versatility. Because of the singular properties of these photochromes, photoisomerizable compounds were obtained with larger thermal stability for their inert cis isomer than for their biologically activity trans state. This enabled selective neuronal firing upon irradiation without background activity in the dark.

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Pèptids, Proteïnes, Monòmers

Subject (English)

Peptides, Proteins, Monomers

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Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Publicacions de projectes de recerca finançats per la UE

Citation

CABRÉ, Gisela, et al. Synthetic Photoswitchable Neurotransmitters Based on Bridged Azobenzenes. Organic Letters. 2019. Vol. 21, num. 10, pags. 3780-3784. [consulted: 12 of August of 2026]. Available at: https://hdl.handle.net/2445/147235

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