Carregant...
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Tots els drets reservats
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/123493
Magnetotactic bacteria powered biohybrids target E. coli biofilms
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Biofilm colonies are typically resistant to general antibiotic treatment and require targeted methods for their removal. One of these methods include the use of nanoparticles as carriers for antibiotic delivery, where they randomly circulate in fluid until they make contact with the infected areas. However, the required proximity of the particles to the biofilm results in only moderate efficacy. We demonstrate here that the non-pathogenic magnetotactic bacteria, Magnetosopirrillum gryphiswalense (MSR-1), can be integrated with drug-loaded mesoporous silica microtubes (MSMs) to build controllable microswimmers (biohybrids) capable of antibiotic delivery to target an infectious biofilm. Applying external magnetic guidance capability and swimming power of the MSR-1 cells, the biohybrids are directed to and forcefully pushed into matured Escherichia coli (E. coli) biofilms. Release of the antibiotic, ciprofloxacin (CFX), is triggered by the acidic microenvironment of the biofilm ensuring an efficient drug delivery system. The results reveal the capabilities of a non-pathogenic bacteria species to target and dismantle harmful biofilms, indicating biohybrid systems have great potential for anti-biofilm applications.
Matèries
Matèries (anglès)
Citació
Citació
STANTON, Morgan m., PARK, Byung-wook, VILELA, Diana, BENTE, Klaas, FAIVRE, Damien, SITTI, Metin, SÁNCHEZ ORDÓÑEZ, Samuel. Magnetotactic bacteria powered biohybrids target E. coli biofilms. _ACS Nano_. 2017. Vol. 11, núm. 10, pàgs. 9968-9978. [consulta: 21 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/123493]