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moncunill2017_2684.pdf (4.22 MB)

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2017-08-23

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cc by (c) Moncunill et al. , 2017
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/116227

RTS,S/AS01E Malaria Vaccine Induces Memory and Polyfunctional T Cell Responses in a Pediatric African Phase III Trial

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http://dx.doi.org/10.3389/fimmu.2017.01008

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Comprehensive assessment of cellular responses to the RTS,S/AS01E vaccine is needed to understand potential correlates and ultimately mechanisms of protection against malaria disease. Cellular responses recognizing the RTS,S/AS01E-containing circumsporozoite protein (CSP) and Hepatitis B surface antigen (HBsAg) were assessed before and 1 month after primary vaccination by intracellular cytokine staining and 16-color flow cytometry in 105 RTS,S/AS01-vaccinated and 74 rabies-vaccinated participants (controls) in a pediatric phase III trial in Africa. RTS,S/AS01E-vaccinated children had significantly higher frequencies of CSP- and HBsAg-specific CD4+ T cells producing IL-2, TNF-alpha, and CD40L and HBsAg-specific CD4+ T producing IFN-gamma and IL-17 than baseline and the control group. Vaccine-induced responses were identified in both central and effector memory (EM) compartments. EM CD4+ T cells expressing IL-4 and IL-21 were detected recognizing both vaccine antigens. Consistently higher response rates to both antigens in RTS,S/AS01E-vaccinated than comparator-vaccinated children were observed. RTS,S/AS01E induced polyfunctional CSP- and HBsAg-specific CD4+ T cells, with a greater degree of polyfunctionality in HBsAg responses. In conclusion, RTS,S/AS01E vaccine induces T cells of higher functional heterogeneity and polyfunctionality than previously characterized. Responses detected in memory CD4+ T cell compartments may provide correlates of RTS,S/AS01-induced immunity and duration of protection in future correlates of immunity studies.

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Malària, Plasmodium falciparum, Àfrica

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Malaria, Plasmodium falciparum, Africa

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Articles publicats en revistes (ISGlobal)

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MONCUNILL PIÑAS, Gemma, ROSA, Stephen c. de, AYESTARAN, Aintzane, NHABOMBA, Augusto j., MPINA, Maximilian, COHEN, Kristen w., JAIROCE, Chenjerai tobias sixpence, RUTISHAUSER, Tobias, CAMPO, Joseph j., HAREZLAK, Jaroslaw, SANZ RÓDENAS, Héctor, DÍEZ-PADRISA, Núria, WILLIAMS, Nana aba, MORRIS, Daryl, APONTE, John j., VALIM, Clarissa, DAUBENBERGER, Claudia, DOBAÑO, Carlota, MCELRATH, M.juliana. RTS,S/AS01E Malaria Vaccine Induces Memory and Polyfunctional T
                Cell Responses in a Pediatric African Phase III Trial. _Frontiers in Immunology_. 2017. Vol. 8, núm. 1008. [consulta: 25 de febrer de 2026]. ISSN: 1664-3224. [Disponible a: https://hdl.handle.net/2445/116227]

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