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moncunill2017_2684.pdf (4.22 MB)

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2017-08-23

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cc by (c) Moncunill et al. , 2017
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/116227

RTS,S/AS01E Malaria Vaccine Induces Memory and Polyfunctional T Cell Responses in a Pediatric African Phase III Trial

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Recurs relacionat

http://dx.doi.org/10.3389/fimmu.2017.01008

Resum

Comprehensive assessment of cellular responses to the RTS,S/AS01E vaccine is needed to understand potential correlates and ultimately mechanisms of protection against malaria disease. Cellular responses recognizing the RTS,S/AS01E-containing circumsporozoite protein (CSP) and Hepatitis B surface antigen (HBsAg) were assessed before and 1 month after primary vaccination by intracellular cytokine staining and 16-color flow cytometry in 105 RTS,S/AS01-vaccinated and 74 rabies-vaccinated participants (controls) in a pediatric phase III trial in Africa. RTS,S/AS01E-vaccinated children had significantly higher frequencies of CSP- and HBsAg-specific CD4+ T cells producing IL-2, TNF-alpha, and CD40L and HBsAg-specific CD4+ T producing IFN-gamma and IL-17 than baseline and the control group. Vaccine-induced responses were identified in both central and effector memory (EM) compartments. EM CD4+ T cells expressing IL-4 and IL-21 were detected recognizing both vaccine antigens. Consistently higher response rates to both antigens in RTS,S/AS01E-vaccinated than comparator-vaccinated children were observed. RTS,S/AS01E induced polyfunctional CSP- and HBsAg-specific CD4+ T cells, with a greater degree of polyfunctionality in HBsAg responses. In conclusion, RTS,S/AS01E vaccine induces T cells of higher functional heterogeneity and polyfunctionality than previously characterized. Responses detected in memory CD4+ T cell compartments may provide correlates of RTS,S/AS01-induced immunity and duration of protection in future correlates of immunity studies.

Matèries

Malària, Plasmodium falciparum, Àfrica

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Malaria, Plasmodium falciparum, Africa

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Articles publicats en revistes (ISGlobal)

Citació

MONCUNILL PIÑAS, Gemma, et al. RTS,S/AS01E Malaria Vaccine Induces Memory and Polyfunctional T
                Cell Responses in a Pediatric African Phase III Trial. Frontiers in Immunology. 2017. Vol. 8, num. 1008. ISSN 1664-3224. [consulted: 13 of August of 2026]. Available at: https://hdl.handle.net/2445/116227

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