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2017-05-02

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cc by (c) Galatas et al., 2017
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/110933

In-Vivo Efficacy of Chloroquine to Clear Asymptomatic Infections in Mozambican Adults: A Randomized, Placebo-controlled Trial with Implications for Elimination Strategies

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http://dx.doi.org/10.1038/s41598-017-01365-4

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Recent reports regarding the re-emergence of parasite sensitivity to chloroquine call for a new consideration of this drug as an interesting complementary tool in malaria elimination efforts, given its good safety profile and long half-life. A randomized (2:1), single-blind, placebo-controlled trial was conducted in Manhica, Mozambique, to assess the in-vivo efficacy of chloroquine to clear plasmodium falciparum (Pf) asymptomatic infections. Primary study endpoint was the rate of adequate and parasitological response (ACPR) to therapy on day 28 (PCR-corrected). Day 0 isolates were analyzed to assess the presence of the PfCRT-76T CQ resistance marker. A total of 52 and 27 male adults were included in the CQ and Placebo group respectively. PCR-corrected ACPR was significantly higher in the CQ arm 89.4% (95%CI 80-98%) compared to the placebo (p < 0.001). CQ cleared 49/50 infections within the first 72 h while placebo cleared 12/26 (LRT p < 0.001). The PfCRT-76T mutation was present only in one out of 108 (0.9%) samples at baseline, well below the 84% prevalence found in 1999 in the same area. This study presents preliminary evidence of a return of chloroquine sensitivity in Mozambican Pf isolates, and calls for its further evaluation in community-based malaria elimination efforts, in combination with other effective anti-malarials. TRIAL REGISTRATION: www.clinicalTrials.gov NCT02698748.

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Malària, Moçambic

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Malaria, Mozambique

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GALATAS, Beatriz, NHAMUSSUA, Lidia, CANDRINHO, Baltazar, MABOTE, Lurdes, CISTERÓ, Pau, GUPTA, Himanshu, RABINOVICH, Regina, MENÉNDEZ, Clara, MACETE, Eusebio víctor, SAUTE, Francisco, MAYOR APARICIO, Alfredo gabriel, ALONSO, Pedro, BASSAT ORELLANA, Quique, AIDE, Pedro carlos paulino. In-Vivo Efficacy of Chloroquine to Clear Asymptomatic Infections
                in Mozambican Adults: A Randomized, Placebo-controlled Trial
                with Implications for Elimination Strategies. _Scientific Reports_. 2017. Vol. 7, núm. 1, pàgs. 1356. [consulta: 24 de gener de 2026]. ISSN: 2045-2322. [Disponible a: https://hdl.handle.net/2445/110933]

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