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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/208412
Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation: A prospective multicentre cohort study
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Background: Interferon-y Release Assays (IGRA) reversions have been reported in different clinical scenarios for the diagnosis of tuberculosis (TB) infection. This study aimed to determine the rate of QuantiFERON-TB Gold Plus (QFT-Plus) reversions during contact investigation as a potential strategy to reduce the number of preventive treatments. Methods: Prospective, multicentre cohort study of immunocompetent adult contacts of patients with pulmonary TB tested with QFT-Plus. Contacts with an initial positive QFT-Plus (QFT-i) underwent a second test within 4 weeks (QFT-1), and if negative, underwent a repeat test 4 weeks later (QFT-2). Based on the QFT-2 result, we classified cases as sustained reversion if they remained negative and as temporary reversion if they turned positive. Results: We included 415 contacts, of whom 96 (23.1%) had an initial positive test (QFT-i). Following this, 10 had negative QFT-1 results and 4 (4.2%) of these persisted with a negative result in the QFT-2 (sustained reversions). All four sustained reversions occurred in contacts with IFN-γ concentrations between ≥0.35 and ≤0.99 IU•mL-1 in one or both QFT-i tubes. Conclusion: In this study, TB contact investigations rarely reveal QFT-Plus reversion. These results do not support retesting cases with an initial positive result to reduce the number of preventive treatments.
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GARCÍA GASALLA, Mercedes, PÉREZ-RECIO, Sandra, GRIJOTA CAMINO, Mª de los desamparados, ANIBARRO, Luis, RABUÑAL REY, Ramón, SABRIÀ, Josefina, GIJÓN-VIDAURRETA, Paloma, POMAR, Virginia, DOMÍNGUEZ-CASTELLANO, Ángel, TRIGO, Matilde, SANTOS, María jesús, CEBOLLERO, Alba, RODRÍGUEZ, Sara, MOGA, Esther, PENAS-TRUQUE, Anton, MARTOS, Carmen, RUIZ-SERRANO, María j., GARCÍA DE CARA, Erika inés, ALCAIDE FERNÁNDEZ DE VEGA, Fernando, SANTÍN CEREZALES, Miguel. Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation: A prospective multicentre cohort study. _PLoS One_. 2023. Vol. 18, núm. 8. [consulta: 20 de desembre de 2025]. ISSN: 1932-6203. [Disponible a: https://hdl.handle.net/2445/208412]