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671476.pdf (967.03 KB)
671476_errata.pdf (110.83 KB)

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2017-02-24

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cc-by (c) Ibáñez Sanz, Gemma et al., 2017
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/127968

Risk model for colorectal cancer in spanish population using environmental and genetic factors: results from the MCC-Spain study

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Recurs relacionat

https://doi.org/10.1038/srep43263

Resum

Colorectal cancer (CRC) screening of the average risk population is only indicated according to age. We aim to elaborate a model to stratify the risk of CRC by incorporating environmental data and single nucleotide polymorphisms (SNP). The MCC-Spain case-control study included 1336 CRC cases and 2744 controls. Subjects were interviewed on lifestyle factors, family and medical history. Twenty-one CRC susceptibility SNPs were genotyped. The environmental risk model, which included alcohol consumption, obesity, physical activity, red meat and vegetable consumption, and nonsteroidal anti-inflammatory drug use, contributed to CRC with an average per factor OR of 1.36 (95% CI 1.27 to 1.45). Family history of CRC contributed an OR of 2.25 (95% CI 1.87 to 2.72), and each additional SNP contributed an OR of 1.07 (95% CI 1.04 to 1.10). The risk of subjects with more than 25 risk alleles (5th quintile) was 82% higher (OR 1.82, 95% CI 1.11 to 2.98) than subjects with less than 19 alleles (1st quintile). This risk model, with an AUROC curve of 0.63 (95% CI 0.60 to 0.66), could be useful to stratify individuals. Environmental factors had more weight than the genetic score, which should be considered to encourage patients to achieve a healthier lifestyle.

Descripció

Aquest article conté una errata annexada

Matèries

Càncer colorectal, Espanya, Genètica, Epidemiologia, Influència del medi ambient en l'home, Factors de risc en les malalties

Matèries (anglès)

Colorectal cancer, Spain, Genetics, Epidemiology, Environmental effects on human beings, Risk factors in diseases

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (ISGlobal)

Citació

IBÁÑEZ SANZ, Gemma, et al. Risk model for colorectal cancer in spanish population using environmental and genetic factors: results from the MCC-Spain study. Scientific Reports. 2017. Vol. 7, num. 43263. ISSN 2045-2322. [consulted: 20 of August of 2026]. Available at: https://hdl.handle.net/2445/127968

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